Hydroxymethylbutyrate

Beta-hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite that has shown anticatabolic actions through inhibiting ubiquitin-proteosome-mediated protein breakdown216 and that may prevent exercise-induced muscle damage.217 It is primarily used by bodybuilders as a supportive measure to induce changes in body composition, and could be a potential dietary supplement for body weight reduction.182 Randomized clinical trials conducted to assess the potential for HMB as an ergogenic aid reported modest effects in reducing fat mass and increasing lean body mass, and no apparent adverse effects (reviewed in references 199 and 218).

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