Effective Treatments For Vitiligo
Cobalamin deficiency is suspected in individuals who display the typical manifestations of deficiency of the vitamin as described in the section above on the effects of deficiency. In addition to the symptoms that may be experienced by individuals that are related to anemia (easy fatigue, shortness of breath, palpitations) and neuropathy (sensory and motor disturbances and memory loss) there are features that may be detected by a physician, including skin pallor (from anemia), abnormalities in neurological examination (sensory loss, abnormal balance and reflexes, mental changes), and epithelial changes (skin pigmentation, smooth tongue). On the basis of any combination of such changes, cobalamin
Injuries, and backache (Ahmad et al., 2006) Expectorant, diuretic, carminative, cleansing, deobstruent in renal stones, amenorrhoea, respiratory ailments, ulcerative scabies, vitiligo, antiphlegmatic attenuant, anthelmintic, antidyspeptic, local anesthetic, hypotensive, antibacterial, anticancer, aids, and antiparasitic (Rizvi et al., 2007) Bronchitis, rheumatism, pyrexia, urogenital diseases such as gonorrhea and syphilis, otitis, cardiotonic, stomachic, and analgesic (Kabirudin & Khan, 2003) Skin diseases, dysentery, and sensitive teeth (Qureshi et al., 2009)
Traditional Medicinal Uses It is frequently used to treat worm and parasitic infection. 6 It has been commonly used for the treatment of psoriasis and vitiligo due to the psoralens and methoxypsoralens present. 7 It is also used to relieve muscle spasms, as carminative, emmenagogue, haemostat, uter-onic, vermifuge, to treat hepatitis, dyspepsia, diarrhoea, bug bite, cancer, cold, fever, snakebite, earache, toothache and as an antidote especially in malarial poisoning. 3,4,8 It is also used as an abortifacient to terminate pregnancy. The plant has been used for pain relief in Mexico. 10
We used anti-IFN-y in patients with psoriasis vulgaris, alopecia areata, vitiligo, acne vulgaris, and herpes simplex type 1, and plan to expand the trials using a humanized monoclonal antibody. Trials are also planned for testing the treatment in other Th-1-mediated skin diseases, including seborrheic dermatitis, rosacea, oral lichen planus, and dermatophyto-sis, which are discussed in the following sections. In most cases, we used two methods of delivery of the antibody intradermal injection around the lesion and intramuscular administration. Thus, anti-IFN-y delivered to the lesion either IM or locally brought the same effect. We believe anticytokine therapy, particularly the removal or inhibition of IFN-y and or TNF-a and IL-1, may be a rational treatment for many severe autoimmune skin diseases that do not respond to standard therapies. 1.3.3 Vitiligo Of four vitiligo patients who received intradermal injections around the lesion, two responded with repigmentation in the treated...
Several genetic loci are shown to be involved in the etiology of multiple autoimmune diseases in humans and support sharing of underlying disease mechanisms across related phenotypes. Associations of certain HLA loci with autoimmune diseases has been reported extensively in SS, SLE, RA, ankylosing spondylitis, psoriasis, multiple sclerosis, and type 1 diabetes.22 A growing list of non-HLA genes also has been implicated in multiple autoimmune diseases. Examples include associations of cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) with AITD, type 1 diabetes mellitus (T1D), celiac disease, Wegener's granulomatosis, SLE, vitiligo, Addison's disease, and RA 23-30 Programmed Death 1(PD-1) with RA, T1D, and SLE 31 and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) with SLE, RA, T1D, Graves' disease, and Hashimoto's thyroiditis.32-37 Interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) are genes strongly associated with SLE for...
Because VZV becomes latent in cranial nerve, dorsal root, and autonomic ganglia along the entire neuroaxis, the virus can manifest anywhere on the body. Typically, the activated virus causes a prodrome consisting of skin sensitivity and mild-to-severe radicular pain, and after five days, a rash appears. The pain is associated with itching and dysesthesia. As with HSV-1, VZV infection decreases sensation in the affected dermatome, yet the affected skin is exquisitely sensitive to touch. The rash may continue to produce pustules that lead to crusting and ulceration. In many affected patients, healing is delayed beyond two weeks and is accompanied by increased skin pigmentation and scarring. Lesions can erupt outside the affected dermatome but rarely cross the midline and are not clinically significant. Distribution of 10 or more lesions outside a single dermatome suggests early evidence of viral dissemination. The term zoster sine herpete is used to describe VZV that is reactivated...
An increase in skin pigmentation and zenith angle of the sun (change in latitude, season, and time of day) and the topical application of a sunscreen can markedly diminish or even prevent the production of vitamin D3 in the skin. Over the age of 65 years, there is a three- to fourfold decline in the synthetic capacity of the skin to produce vitamin D3. Excessive exposure to sunlight cannot cause vitamin D3 intoxication because once previta-min D3 and vitamin D3 are made in the skin, excessive quantities are rapidly destroyed by sunlight (Figure 3).
In many instances, the efficacy of centuries-old traditional herbal treatments has been confirmed by modern research. For example, extracts of the Ayurvedic herb Psoralea corylifolia have been used for over 3,000 years to treat a skin pigmentation condition know as vitiligo.2 Our grandmothers also seem to have been right to recom
To explore the immunotherapeutic potential of other tumor antigen-encoding genes, Steitz et al. (102) examined the effect of TRP2 DNA vaccination. They found that immunization of C57BL 6 mice with both autologous murine and xenogenic human TRP2 DNA provided significant protection against metastatic growth of B16 melanoma in lung, with the xeno-gene displaying more pronounced protective effect and resulting in vitiligo-like coat depigmentation as a sign of autoimmune-mediated destruction of melanocytes. Interestingly, in this study, induction of protective immunity was found associated with both TRP2-reactive antibodies and CD8 + T cells.
Groups from Vienna, Freiburg, and Wurzburg performed a phase I trial to evaluate the safety and tolerability of repeated skin injections of IL-2-transfected autologous melanoma cells into patients with advanced disease using a transferrin-me-diated and adenovirus-enhanced transfection system (114). Fifteen patients received 2 to 8 skin vaccinations of either 3 x 106 (intradermal) or 1 x 107 (half intradermal, half subcutaneous) transfected melanoma cells per vaccination (secreting 140 to 17,060 biological response modifier program units of IL-2 106 cells 24 h). Overall, the vaccine was well tolerated. All patients displayed modest local reactions (erythema, induration, and pruritus) and some experienced flulike symptoms. Apart from newly appearing (4 of 14) and increasing (5 of 14) antiadenovirus and newly detectable antinuclear antibody titers (1 of 15), recipients developed de novo or exhibited increased melanoma cell-specific delayed-type hyper-sensitivity (DTH) reactions (8 of 15)...
Cell response to autologous tumor cells was obtained only in 1 of 6 cases studied. More recently, in a phase I II study, Osanto et al. (118) applied an IL-2-secreting allogeneic melanoma cell line in 3 successive vaccinations (each 6 X 107 cells) to 33 melanoma patients. No major side effects were recorded. Two patients achieved complete or partial regression of subcutaneous metastases. Seven patients had protracted stabilization (4 to 46 months) of soft-tissue metastases, including 1 who developed vitiligo after vaccination. Immune responses to the vaccine could be detected in 67 of the 27 patients measured. In 2 of 5 patients, the frequency of antiautologous tumor CTLs was significantly increased by vaccination.
Melanoma is a malignant tumor of neuroectodermal origin with an increasing incidence and mortality. It needs to be detected and eliminated early because melanoma is characterized by its high resistance to conventional therapies, including surgery and chemotherapy (33,40,41). However, melanoma is supposed to be one of the most immunogenic tumors, which is demonstrated by tumor infiltrating lymphocytes (TIL) destroying melanoma cells (36,38). This may also be responsible for the occurence of spontaneous partial or complete melanoma regression and for the concomitant destruction of melan-ocytes in benign lesions, leading to clinical phenomena such as halo nevi, uveitis, and vitiligo in melanoma patients.
Excessive intake All As compounds are toxic in more than miniscule amounts, causing gastrointestinal distress, skin pigmentation, and keratosis (arsenicism), cancer of skin, lung, bladder, and other sites, gangrene of extremities (blackfool disease), anemia, symmetric peripheral neuropathy, and damage lo brain and liver. It is genoloxic and mutagenic at low concentrations. No As-containing supplements should be used and the arsenic content of public water supplies has been limited by the US Environmental Protection Agency to less than K)p.g 1 due to concerns about the potential of arsenic to cause cancer of the skin, bladder, lung, and other organs, even al very low levels of intake.
Stomatosis (f12 PHR) Streptococcus (12 X9354029 X15892950) Stroke (1 JN131 1010s) Swelling (f AKT FAD FAY GHA JFM) Syncope (f KAB) Tapeworm (f JFM) Thirst (f KAB) Thrombosis (f123 APA EGG GHA KAL KOM PH2) Toothache (f1 TRA) Tonsilosis (f1 LAW) Trachoma (f DAA) Trichomonaisis (f1 DAA) Trypanosomiasis (1 KAL) Tuberculosis (f1 APA EGG GHA JFM KAL TRA) Typhoid (f DAA) Typhus (f1 DAD KAL) Ulcer (f1 AKT X11238826) Ulcus cruris (12 KAL) UTIs (f1 WHO) Vaginosis (f12 APA DAA KAL) Varicosity (f DLZ JFM) Virus (1 PH2 TRA) Vitiligo (f EGG) Wart (f EGG PHR PH2) Wen (f JLH) Whitlow (f JLH) Worm (f1 AKT APA EGG JFM VOD) Wound (f GHA PHR) Yeast (f12 APA CAN JAD WO2). Peruvians suggest rubbing cut garlic on corns, dandruff, infection, itch, rheumatism, sores, vitiligo, and warts (EGG).
THE EARLIEST MEMBERS of Homo sapiens, or modern humans, evolved in Africa between 120,000 and 100,000 years ago and had darkly pigmented skin adapted to the conditions of UV radiation and heat that existed near the equator. As modern humans began to venture out of the tropics, however, they encountered environments in which they received significantly less UV radiation during the year. Under these conditions their high concentrations of natural sunscreen probably proved detrimental. Dark skin contains so much melanin that very little UV radiation, and specifically very little of the shorter-wavelength UVB radiation, can penetrate the skin. Although most of the effects of UVB are harmful, the rays perform one indispensable function initiating the formation of vitamin D in the skin. Dark-skinned people living in the tropics generally receive sufficient UV radiation during the year for UVB to penetrate the skin and allow them to make vitamin D. Outside the tropics this is not the case....
Leucoderma partial or total loss of skin pigmentation, often occurring in patches. Also called vitiligo. leucodermic an agent that can cause partial or total loss of skin pigmentation, often occurring in patches. Also called vitiligo vitiligo a condition in which destruction of melanocytes in small or large circumscribed areas results in patches of depigmentation often having a hyperpigmented border, and often enlarging slowly
Vitiligo is a loss of pigmentation of the skin in well-defined areas. It may occur anywhere on the body and at any age. Vitiligo is not a common problem in adults with Down's syndrome, but is still more common than in the general population. The cause is unknown, but it may be caused by auto-antibodies destroying melanocytes, which are cells in the skin that produce pigment.
The evolution of skin pigmentation is linked with that of hairlessness, and to comprehend both these stories, we need to page back in human history. Human beings have been evolving as an independent lineage of apes since at least seven million years ago, when our immediate ancestors diverged from those of our closest relatives, chimpanzees. Because chimpanzees have changed less over time than humans have, they can provide an idea of what human anatomy and physiology must have been like. Chimpanzees' skin is light in color and is covered by hair over most of their bodies. Young animals have pink faces, hands, and feet and become freckled or dark in these areas
This is a rare multisystem disorder due to infection by an organism called Tropheryma whippelii that invariably affects the small bowel and may also be associated with skin pigmentation, arthralgias, endocarditis, and other heart problems and central nervous system abnormalities. In the small bowel, it causes malabsorption with diarrhea, steatorrhea, abdominal pain, distension, and weight loss. It is diagnosed by the presence of periodic acid-Schiff-positive granules in macrophages.
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