Vitamin B6 and the Premenstrual Syndrome

Studies during the 1960s showing that vitamin B6 supplements were effective in overcoming some of the side effects of (high-dose) oral contraceptives have led to the use of vitamin B6 in treatment of the premenstrual syndrome - the condition of nervousness, irritability, emotional disturbance, headache, and/or depression suffered by many women for up to 10 days before menstruation.

Twelve placebo-controlled, double-blind trials of vitamin B6 in the premenstrual syndrome were reviewed by Kleijnen et al. (1990); the evidence of beneficial effects was weak. In three of the studies, there was a significant beneficial effect of vitamin B6 supplements of 100 to 500 mg per day. Five studies yielded ambiguous results and a further three reported the following: an improvement for 82% of subjects receiving 100 mg of vitamin B6 per day, and 70% of those receiving placebo; apositive trend but no statistical significance using 200 mg per day; and disappointing and not clear results using 50 mg per day. The remaining four studies reported no beneficial effects of doses between 100 to 500 mg per day. A systematic review of 25 controlled trials concluded that only 10 met the criteria for inclusion, and concluded that overall the results were suggestive of beneficial effects, but did not provide evidence of efficacy (Wyatt et al., 1999).

Interestingly, one study, which reported no significant difference between vitamin B6 (100 mg per day) and placebo, showed that whichever treatment was used second in a double-blind crossover trial was significantly better than the treatment used first (Hagen et al., 1985).

Curing Premenstrual Tension Naturally

Curing Premenstrual Tension Naturally

Is Moodiness, Pain and Bloating Paralyzing Your Life In the Days Leading Up to Your Period? Just what is premenstrual tension also known as PMS anyway and why does it cause most women so much misery?

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