Upper Levels of Niacin Intake

Nicotinic acid (but not nicotinamide) causes a marked vasodilatation, with flushing, burning, and itching of the skin. Very large single doses of nicotinic acid may cause sufficient vasodilatation to lead to hypotension; after the administration of 1 to 3 g of nicotinic acid daily for several days, the effect wears off to a considerable extent. A number of nicotinoyl esters have been developed to permit sensitive patients to benefit from the hypolipidemic effect of nicotinic acid without the vasodilatation. The tolerable upper limit is 35 mg per day for adults (Institute of Medicine, 1998).

At intake in excess of 1 g of niacin per day, there is evidence of toxicity, with changes in liver function tests, carbohydrate tolerance, and uric acid metabolism that are reversible on withdrawal of niacin (Parsons, 1961a, 1961b). Baggenstoss and coworkers (1967) reported changes in liver ultrastructure in patients receiving high doses of niacin, including dilatation of the endoplasmic reticulum with formation of vesicles and sacs, and a diminution in the parallel arrays of rough endoplasmic reticulum, with fewer ribosomes on the outer surface. There was also elongation of the mitochondria, withbud-like projections and crystalloid inclusions. The mechanism of niacin hepatotox-icity is not known. Sustained release preparations are associated with more severe liver damage than crystalline preparations, presumably because they permit more prolonged maintenance of high concentrations of the vitamin, whereas after an acute high dose there is normally considerable excretion of unchanged nicotinic acid and nicotinamide, as the renal threshold is exceeded.

The European Health Food Manufacturers' Federation restricts over-the-counter supplements to 500 mg per day (Shrimpton, 1997). Where niacin is being used to treat clinically significant hyperlipidemia, and in trials for the prevention of type I diabetes mellitus, a tentative upper limit has been set at 3 g per day (Knip et al., 2000).


Nicotinic acid is used clinically in large doses (of the order of 1 to 3 g per day) as a hypolipidemic agent. It reduces both triglycerides and total cholesterol by about 20%, acting as an inhibitor of cholesterol synthesis. It has a more marked effect on cholesterol in low-density and very low-density lipoproteins, and increases high-density lipoprotein cholesterol; nicotinamide is ineffective (Brown, 1995; Capuzzi et al., 2000). It also inhibits the release of nonesterified fatty acids from adipose tissue by inhibiting the adenylate cyclase that is activated in response to hormonal stimulation, thus decreasing synthesis of very low-density lipoprotein in the liver, and stimulates the 5-lipoxygenase pathway, leading to increased formation of prostaglandin E2, thromboxane B2, and leukotriene E4 from arachidonic acid (Saareks et al., 1999). There is, however, some evidence that doses of about 1 g of nicotinic acid per day may lead to elevation of plasma homocysteine (Section, which would reduce the benefits to be expected from its hypolipidemic action (Garg et al., 1999).

In experimental animals, nicotinamide protects against the destruction of pancreatic f-islet cells caused by diabetogenic agents, such as alloxan and streptozotocin. Type I diabetes mellitus is caused by autoimmune destruction of p -cells, and autoantibodies against ft -cell proteins can be detected in the circulation several years before the clinical onset of diabetes. It has been suggested that nicotinamide may delay the development of diabetes in susceptible subjects (Gale, 1996a, 1996b). Nicotinamide may act by either inhibiting ADP-ribosyltransferase (Section8.4.2) andpoly(ADP-ribose) polymerase (Section 8.4.3) or by inhibiting the induction of cell surface antigens by interferon and tumor necrosis factor (Kolb and Burkart, 1999; Kim et al., 2002). Although nicotinamide has no effect once diabetes has developed (Vidal et al., 2000), preliminary studies in people at risk of developing type I diabetes are promising. A prospective study involving first-degree relatives of patients with type I diabetes, who are being screened for autoantibodies and randomized to receive either nicotinamide or placebo, the European Nicotinamide Diabetes Intervention Trial (ENDIT) is expected to report in 2004 (Schatz and Bingley, 2001).

Gram doses of nicotinamide have been used in so-called orthomolecular psychiatry as a treatment for schizophrenia, originally because of the similarities between schizophrenia and the depressive psychosis of pellagra. The underlying rationale for this use is that such high doses of niacin may deplete methyl donors, and at least one of the theories of the biochemical basis of schizophrenia was that the condition is caused by inappropriate methylation of neurotransmitter metabolites to yield psychotogenic compounds (Hoffer et al., 1957). There is no independent confirmation of the efficacy of nicotinamide in the treatment of schizophrenia.


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References cited in the text are listed in the Bibliography.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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