Upper Levels of Intake

Vitamin E seems to have very low toxicity, and habitual intake of supplements of 200 to 600 mg per day (compared with an average dietary intake of 8 to 12 mg) seems to be without untoward effect; there are no consistent reports of adverse effects up to 3,200 mg per day, suggesting that an acceptable daily intake is in the very wide range between 0.15 to 2 mg per kg of body weight; the European Health Food Manufacturers' Association suggests an upper limit of 800 mg per day from supplements (Shrimpton, 1997).

Very high intakes may antagonize vitamin K and hence potentiate anticoagulant therapy. This is probably the result of inhibition of the vitamin K quinone reductase, but a-tocopheryl quinone may compete with vitamin K hydroquinone and hence inhibit carboxylation of glutamate in target proteins (Section 5.3.1).

The U.S./Canadian tolerable upper level is set at 1,000 mg per day, based on reports of prolonged prothrombin time in people receiving anticoagulants and consuming 1,100 to 2,100 mg of vitamin E per day. It is noteworthy that although the report specifically excluded the 2S isomers of synthetic a-tocopherol from calculations of nutritional requirements, this tolerable upper level includes all forms of the vitamin, regardless of their tissue retention and biological activity (Institute of Medicine, 2000).

My Life My Diet

My Life My Diet

I lost over 60 pounds and 4+ inches off my waist without pills, strenuous exercise, or any of the things that the diet experts tell you to do...and I did it in less than 4 months! If you have the desire, and can read through my e-book , then this is for you! I could have easily made it a lot more difficult, with stacks of information that people will never read, but why?

Get My Free Ebook

Post a comment