Possible Pellagragenic Toxins

Early studies suggested the presence of a toxin from some samples of maize that was pellagragenic in experimental animals. Schoental (1983) suggested that mycotoxins resulting from fungal spoilage of maize and other grain stored under damp conditions may have been responsible for some outbreaks of pellagra. Certainly, the only known outbreak of the disease in Mexico can be traced to a consignment of maize that was shipped under damp conditions and had a significant fungal overgrowth. As discussed in Section 8.4.2 and Section 8.4.3, a number of bacterial, fungal, and environmental toxins activate ADP-ribosyltransferase orpoly(ADP-ribose) polymerase, and it is possible that chronic exposure to such toxins will deplete tissue NAD(P) and be a contributory factor in the development of pellagra when intakes of tryptophan and niacin are marginal.

Arthritis Relief and Prevention

Arthritis Relief and Prevention

This report may be oh so welcome especially if theres no doctor in the house Take Charge of Your Arthritis Now in less than 5-Minutes the time it takes to make an appointment with your healthcare provider Could you use some help understanding arthritis Maybe a little gentle, bedside manner in your battle for joint pain relief would be great Well, even if you are not sure if arthritis is the issue with you or your friend or loved one.

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