No2 h2o

Figure 4.6. Reactions of a - and y-tocopherol with peroxynitrite.

y-tocopheryl orthoquinorie (y-tocored)

Figure 4.6. Reactions of a - and y-tocopherol with peroxynitrite.

therefore causing increased oxidative damage to lipids, especially in the absence of coantioxidants such as ascorbate or ubiquinone (Upston et al., 1999; Carret al., 2000).

4.3.1.2 Reaction of Tocopherol with Peroxynitrite Nitric oxide can react with superoxide to yield peroxynitrite, which, although not a radical, can react with proteins and lipids. Both a- and y-tocopherol react with peroxynitrite; y-tocopherol is more active and undergoes nitration as shown in Figure 4.6; it is significantly more active in preventing lipid peroxidation by peroxynitrite than is a-tocopherol, which does not undergo nitration (Jiang et al., 2001).

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