Metabolic Functions Of Thiamin

The studies of Peters in the 1920s and 1930s (Peters, 1963) established the coenzyme role of thiamin in the oxidative decarboxylation of pyruvate. Thiamin diphosphate is the coenzyme for three multienzyme complexes in mammalian mitochondria that are involved in the oxidative decarboxylation of oxo-acids: pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase in central

NADH

Figure 6.2. Reaction of the pyruvate dehydrogenase (EC 1.2.4.1) complex. CoASH, free coenzyme A.

NADH

Figure 6.2. Reaction of the pyruvate dehydrogenase (EC 1.2.4.1) complex. CoASH, free coenzyme A.

energy-yielding metabolic pathways, and the branched-chain oxo-acid dehydrogenase in the catabolism of leucine, isoleucine, and valine.

Later studies established the coenzyme role of thiamin diphosphate in transketolase in the pentose phosphate pathway. More recent studies have shown that thiamin triphosphate acts to regulate a chloride channel in nerve tissue.

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