Biosynthesis of Taurine

As shown in Figure 14.7, taurine is a ^-amino sulfonic acid (2-aminoethane sulfonic acid) and can be synthesized from cysteine by three pathways:

1. Oxidation to cysteine sulfinic acid, followed by decarboxylation to hypo-taurine and oxidation to taurine. In most tissues, it is the decarboxylation

ch2-

-sh cysteine decarboxylase ch2—nh3+

cysteamine -02

cysteine oxidase ch2—s02"

COO" cysteine sulfinic acid o2

cysteine sulfinate ^ oxidase

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