Sixty-five RCT articles were evaluated for the effect of weight loss on serum/plasma concentrations of total cholesterol, low-density lipoprotein (LDL)-cholesterol, very low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein (HDL)-cholesterol. Studies were conducted on individuals over a range of overweight and lipid levels. Weight loss in 52 of these trials was induced by various lifestyle modifications, including diet modification (reducing calories, or saturated fat and cholesterol, or both) and increased physical activity.
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