Serum Plasma Lipids and Lipoproteins

Natural Cholesterol Guide

Beat Cholesterol Book

Get Instant Access

Sixty-five RCT articles were evaluated for the effect of weight loss on serum/plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol. In 52 of these trials weight loss was induced by various lifestyle modifications, including diet modification and increased physical activity. 356, 365, 367-370, 373, 380, 384, 399-406, 412, 431, 433, 434, 440,

446, 447, 469, 470, 473, 475, 484, 490, 677-679, 681, 683-685, 688-690, 693, 694, 700-709

Thirteen RCT articles were reviewed that considered the effects of pharmacological therapy on weight loss and subsequent changes in total serum cholesterol level.

Lifestyle Trials

Of the 52 lifestyle trials:

■ 27 RCT articles examined the effect on plasma lipids of weight loss induced by diet alone, i.e., these studies simply included a diet intervention without a formal physical activity program or medications. 356,

400, 402, 412, 431, 433, 440, 484, 490, 677, 679, 683, 706, 708, 709

■ 11 RCT articles examined weight loss induced by increased physical activity alone;

365, 401, 404, 406, 447, 678, 685, 700, 703, 705, 707 and

■ 14 RCT articles considered the combination of caloric restriction and physical activity. 367,

380, 384, 403, 405, 434, 446, 469, 470, 473, 475, 681, 684, 694

Of the 52 lifestyle trials reviewed, 14 met the criteria for inclusion. 365, 368, 37°, 373 38°, 384, 399-406 The remaining 38 were not considered because: ■ The no-treatment control group also lost weight 434, 446, 469, 470, 473, 475, 484, 490, 677-679, 683, 684, 688, 690,

There was no appropriate control group; 431, 700

There was no difference in weight loss between the treatment and control group; 447,

702, 703

The dropout rate was more than 35 percent; 685

The population was not overweight; 689, 690

The results were not reported according to randomized treatment; 681

The outcome measures were not reported separately for the overweight and not overweight groups; 440

There was no measure of at least one lipopro-tein fraction or measure of change in lipids between the beginning and end of treatment;

■ Lipoprotein concentrations could not be determined from the figures in the paper, 707 or it was difficult to get precise measures. 369

Pharmacotherapy Trials The effects of pharmacological therapy on weight loss and subsequent changes in total serum cholesterol levels were evaluated by examining 13 RCT articles: 5 on the effect of dexfen-fluramine; 386, 390- 393 2 on fluoxetine; 408, 711 1 on the combination of phentermine and fenfluramine (phen/fen); 395 2 on orlistat; 407, 710 1 on testosterone decanoate; 698 1 on ephedrine alone or in combination with caffeine; 697 and 1 on a beta adrenoceptor agonist. 696 Of the 13 pharma-cotherapy trials reviewed, 8 were accepted and 5 were not considered for these reasons:

■ The main outcome of the treatment was not weight loss; 698

■ The drug in question is not currently being recommended for weight loss; 696-698

■ The dropout rate was more than 35 percent; 711 or

■ It was a marginal 12-week study. 710

Was this article helpful?

0 0
Lower Your Cholesterol In Just 33 Days

Lower Your Cholesterol In Just 33 Days

Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!

Get My Free Ebook


Post a comment