Pathogenesis

While sarcoidosis has an unknown etiology, it is postulated to result from exposure to environmental agents in a genetically susceptible host. This hypothesis is supported by racial differences and clusters of disease, implying a genetic predisposition, and the immunophenotype of an antigen-driven response with restricted T-cell receptor usage. Studies throughout the world reveal different genetic associations depending on ethnicity; the most commonly associated genes are class I HLA-A1 and -B8 and class II HLA-DR3. The mode of inheritance is likely polygenic (30,32).

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