Neurofibromatosis

Also known as Von Recklinghausen's disease, neurofibromatosis is an autosomal-dominant hereditary disorder that causes CNS tumors and cutaneous neurofibromata. The most common manifestation of this disease that is encountered in the practice of otolaryngology is the acoustic neuroma. Occasionally, a lesion involves the larynx (13). Figure 6 depicts a very large lesion in the posterior glottis of an infant. Treatment is difficult because complete removal of such a lesion in the larynx is usually not possible without total laryngectomy, and recurrence is common with partial removal.

FIGURE 6 Large neurofibroma of the posterior glottis in an infant.

REFERENCES

1. Lebovics RS, Hoffman GS, Leavitt RY, et al. Management of subglottic stenosis in patients with Wegener's granulomatosis. Laryngoscope 1992; 102(12 Pt 1):1341—1345.

2. Brazeau-Lamontagne L, Charlin B, Levesque RY, et al. Cricoarytenoiditis: CT assessment in rheumatoid arthritis. Radiology 1986; 158(2):463-466.

3. Woo P, Mendelsohn J, Humphrey D. Rheumatoid nodules of the larynx. Otolaryngol Head Neck Surg 1995; 113(1):147-150.

4. Friedman BA. Rheumatoid nodules of the larynx. Arch Otolaryngol 1975; 101(6):361-363.

5. Teitel AD, MacKenzie CR, Stern R, et al. Laryngeal involvement in systemic lupus erythematosus. Semin Arthritis Rheum 1992; 22(3):203-214.

6. Lewis JE, Olsen KD, Kurtin PJ, et al. Laryngeal amyloidosis: a clinicopathologic and immunohistochemical review. Otolaryngol Head Neck Surg 1992; 106(4):372-377.

7. Hale EK, Bystryn JC. Laryngeal and nasal involvement in pemphigus vulgaris. J Am Acad Dermatol 2001;44(4):609-611.

8. Whiteside OJ, Martinez Devesa P, Ali I, et al. Mucous membrane pemphigoid: nasal and laryngeal manifestations. J Laryngol Otol 2003; 117(11):885-888.

9. McCaffrey TV, McDonald TJ, McCaffrey LA. Head and neck manifestations of relapsing polychondritis: review of 29 cases. Otolaryngology 1978; 86(3 Pt 1):473-478.

10. Neel HB III, McDonald TJ. Laryngeal sarcoidosis: report of 13 patients. Ann Otol Rhinol Laryngol 1982; 91(4 Pt 1):359-362.

11. Krespi YP, Mitrani M, Husain S, et al. Treatment of laryngeal sarcoidosis with intralesional steroid injection. Ann Otol Rhinol Laryngol 1987; 96(6):713-715.

12. Wu CL, Linne OC, Chiang CW. Herpes zoster laryngis with prelaryngeal skin erythema. Ann Otol Rhinol Laryngol 2004; 113(2):113-114.

13. Holt GR. E.N.T. manifestations of Von Recklinghausen's disease. Laryngoscope 1978; 88(10): 1617-1632.

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