This book provides a great wealth of the most current information for today's readers and will serve as a respected resource for decades to come.

The two editors, one from otolaryngology-head and neck surgery and the other from rheumatology, are distinguished scientist-clinicians who have made important contributions to our knowledge of basic and clinical immunology. They have designed a work with a unique perspective: First, to present the fundamental information on a multitude of diseases that have manifestations in the head and neck, and, second, to relate commonly encountered head and neck symptoms and signs to an array of diseases and disorders that should be considered in the differential diagnosis. In the first instance, the diseases are grouped under the broad rubrics of immune disorders, infections, and neoplasia, with immunology as the underlying basic theme and emphasis on pathophy-siology and molecular medicine. In the second instance, the clinical approach to problemsolving analyzes the possible causes of the patient's symptoms and signs, and presents evidence-based therapeutic options. Both come together under the editors' guidance to make fascinating reading and to produce a treasure-trove of knowledge. Both are equally rewarding to specialists in neurology, rheumatology, infectious diseases, oncology, dermatology, and otorhinolaryngology-head and neck surgery, and generalists in pediatrics, internal medicine, and family practice. This important book provides an outstanding educational experience for students, residents, fellows, and practitioners of both groups.

The authors of the chapters have been selected for their preeminence in clinical management, as well as having made seminal contributions through research to their topics, thus assuring authoritative presentation of them.

The readers become active members of the team and are involved in the intellectual process that states that everything in medicine is related to everything else in medicine, each one illuminating the others. The reader's role is reminiscent of my role in a little game I used to enjoy playing with the residents, which was occasioned by an offhand remark that I was dwelling on a subject that was not germane to the specialty of otorhinolaryngology-head and neck surgery. At this, I would challenge them to name any other topic in the basic or clinical sciences of medicine that was not related to otorhinolaryngology-head and neck surgery and let me try to mention an important connection of it to their specialty; and, no matter what they chose, I would, with very few exceptions, be able to relate it in a meaningful way to their principal interest. This book provides the same scholarly satisfaction in the unity of medicine.

The design, organization, and execution of this book make it reader-friendly, and its intellectual tone ensures an informative and enjoyable educational experience.

Professor Emeritus, University of Pennsylvania School of Medicine

Philadelphia, Pennsylvania, U.S.A.

Former Director, National Institute on Deafness and Other Communication Disorders National Institutes of Health Bethesda, Maryland, U.S.A.

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