Diagnosis

The diagnosis of LCH can be challenging. A pathological diagnosis is needed for confirmation. Langerhans cells are present to varying degrees within individual specimens. Other inflammatory cells are also present. Over time, the primary site may show fibrosis predominating the lesion. The presence of the Langerhans cell on microscopy suggests the diagnosis, but immunohistochemical staining for S-100 or CD1a is needed to confirm the diagnosis. The presence of Birbeck granules, which can only be identified via EM, can also confirm the diagnosis. Once the diagnosis is made, a comprehensive evaluation, including a skeletal survey and basic laboratory evaluation, are important (2,3).

Was this article helpful?

0 0
Natural Vertigo And Dizziness Relief

Natural Vertigo And Dizziness Relief

Are you sick of feeling like the whole world Is spinning out of control. Do You Feel Weak Helpless Nauseous? Are You Scared to Move More Than a Few Inches From The Safety of Your Bed! Then you really need to read this page. You see, I know exactly what you are going through right now, believe me, I understand because I have been there & experienced vertigo at it's worst!

Get My Free Ebook


Post a comment