The diagnosis of glucagonoma is made by three criteria: (i) an elevated serum glucagon level by radioimmunoassay; (ii) radiographically or histologically demonstrable neuroendocrine tumor; and (iii) characteristic clinical features (20). NME reportedly has been the single most consistent clinical finding that has led to diagnosis of glucagonoma. Other clinical features suggestive of glucagonoma include diabetes, weight loss, anemia, stomatitis, glossitis, dystrophic nails, and alopecia.

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