WG is an idiopathic systemic inflammatory disease typically presenting with abnormalities affecting the upper and lower respiratory tracts and the kidneys. However, any organ system can be involved (1). WG is often referred to as an "antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitis," as are microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CSS) (2). In a minority of patients, however, medium- and large-sized vessels can also be affected; the presence of vasculitis is not necessary for the diagnosis; and ANCA may be lacking in a significant number of cases (3). The terminology "ANCA vasculitis" or "ANCA-associated vasculitis" remains controversial because the absence of ANCA in subsets of patients with these diseases suggests that it is not essential for pathogenesis. Nonetheless, it is possible that its presence may play a role in modifying the disease phenotype or severity.

Was this article helpful?

0 0
Natural Vertigo And Dizziness Relief

Natural Vertigo And Dizziness Relief

Are you sick of feeling like the whole world Is spinning out of control. Do You Feel Weak Helpless Nauseous? Are You Scared to Move More Than a Few Inches From The Safety of Your Bed! Then you really need to read this page. You see, I know exactly what you are going through right now, believe me, I understand because I have been there & experienced vertigo at it's worst!

Get My Free Ebook

Post a comment