Complications And Prognosis

The polyps in PJS are benign hamartomas and have a low rate of malignant transformation, but because the polyps progress with age, they can lead to recurrent abdominal pain, bleeding, anemia, intussusception, and obstruction. Patients with PJS are susceptible to a multitude of internal malignancies, including tumors of the gastrointestinal tract, pancreas, testicles, ovaries, cervix, and uterus; aggressive screening protocols as mentioned above are recommended to decrease morbidity and mortality.

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