Stress

-20 -10 0 10 20 30 40 50 60 -20 -10 0 10 20 30 40 50 60 Time (min)

STRESSED CONTROLS SSR149415 (30 mg/kg po)

STRESSED CONTROLS DIAZEPAM (2 mg/kg ip)

Fig. 6. Effects of the Vlb receptor antagonist, SSR149415, on autonomic markers of the stress response produced by restraint as measured by radiotelemetry. It consists notably of significant elevations of blood pressure and heart rate. SSR149415 and diazepam were administered 60 and 30min prior to restraint, respectively. Data represent mean ± S.E.M. * /><0.05, **P<0.0l (vs stressed controls).

Studies using SSR149415 targeted to specific regions such as the amygdala, septum or hippocampus, are in progress. They should help to clarify the involvement of the Vib receptor in anxiety and depression. In conclusion, the development of nonpeptide V,b receptor antagonists opened a new era for examining the role of AVP in animal models of stress, and may provide a novel avenue for the treatment of affective disorders.

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T. Sleekier, N.H. Kaiin andJ.M.H.M. Reul (Eds.) Handbook of Stress and the Brain, Vol. 15 ISBN 0-444-51823-1

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