Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239-3098, USA
Abstract: The corticotropin-releasing factor (CRF) family constitutes a primary system that mediates adaptive neuroendocrine, autonomic, and behavioral responses to stress, a process known as allostasis. Genetically engineered mice provide a powerful tool for dissection of corticotropin pathways. A collection of models have been generated that harbor specific alterations in ligands, receptors, and the binding protein. In this review, we describe prominent neuroendocrine and behavioral features of these genetic mouse models that have led to new insights of allostatic regulation and associated pathology.
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