dominants on the basis of both agonistic and nonagonistic behaviors, wound patterns and weight changes. Their behavior changes suggest chronic defensiveness and are also broadly isomorphic to many of the symptoms of depression (Blanchard et al, 1993). Drug administration began on day 3, after determination of dominance, and continued twice daily until day 14. Males treated with fluoxetine typically showed more weight loss (data not shown) and wounding than vehicle controls (Fig. 4A). Together with previous data, this was hypothesized to reflect reduced defensiveness in the presence of the dominant. SSR149415 dose groups showed higher weight loss (data not shown) and wounding relative to vehicle controls (Fig. 4A). Interestingly, on average over 3 days, vehicle subordinate controls

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