Time (mir)

Fig. 4. The effects of vehicle or diazepam (1, 2, 4, and 8mg/kg IP) are shown on core body temperature in a stress-induced hyperthermia procedure in three strains of mice (129SvEv, TV =12; Swiss-Webster, TV =12; C57BL/6J, N=\2) using continuous telemetric measurement of core body temperature. Each male mouse from each strain randomly obtained vehicle or all doses of diazepam over a 3-week period (at least two washout days between treatments). Animals obtained an intraperitoneal injection of either saline or one of the diazepam doses 60min (first arrow) before the rectal temperature measurement (r=0min, second arrow).

a dose-dependent way, and has no intrinsic effects on core body temperature. There is also a difference in the basal core body temperature of the three strains: at the start of the experiments (around 09:00 h) the mean core body temperature is 36.5, 36.0, and

35.5°C, for the SW, 129SvEv, and C57BL/6 strains, respectively. This is a constitutive difference between the three strains. Telemetric measurements of core body temperature of these three strains over a 7-day period clearly shows basal differences in Tm (12-12 h o r 36 5

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