B9

Fig. 4. Daily abdominal temperature (mean ± s.d.) of unrestrained rabbits for the first seven days after implantation of osmotic pumps (day 1) continuously infusing saline (open symbols, n — 5) or a Gram-negative pyrogen, lipopoly-saccharide (0.2 ng^1 kg"1 min~', closed symbols, w = 5) sub-cutaneously. Arrow indicates time of implantation. Daily temperatures are averages of 5-min values for each rabbit. Dotted line represents mean daily body temperature of rabbits implanted with loggers only.

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