RLS and rheumatic diseases

In the rheumatoid arthritis (RA) patient population, increased prevalence of RLS has been reported by several investigators. Reynolds et al studied hospitalized RA patients employing a 'control' group of osteoarthritis (OA) patients, and found a 30% prevalence of RLS in RA compared to 3% in OA (Reynolds G et al, 1986). A subsequent study again comparing RA and OA found comparable prevalence rates for RLS of 25% in RA and 4% in OA (Salih AM, et al, 2004). Auger et al in their study of MS patients employed a RA patient group for contrast, finding a prevalence rate for RLS of 31% in their RA group (Auger C, et al, 2005). A more recent study employing the 2003 IRRLSG criteria for RLS found a prevalence of RLS of 27.7% in RA and a prevalence of 24.4% in OA patients (Taylor-Gjevre, et al, 2009). Increased frequency of RLS has also been reported in other rheumatic disease populations, including Sjogren's Syndrome, scleroderma and fibromyalgia patients (Taylor-Gjevre, et al, 2011). A recent study of RLS in Systemic Lupus Erythematosus patients has also suggested an increased prevalence in that population (Hassan N, et al, 2011).

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