Skin Diseases Involving Th1Th2 Cytokines

Atopic dermatitis is a disease in which Th-1 and Th-2 cytokines are involved depending on the phase of the disease. IFN-y-positive cells are predominant in the skin lesions. In the initiation phase, IL-4 production by Th-2 and Th-0 cells is predominant over IFN-y production by Th-1 cells, while in the late and chronic phase, the situation is reversed with IFN-y production dominant over IL-4, IL-5, and IL-13 production by Th-2 and Th-0 cells (Thepen et al. 1996). Thus, in the initiation phase, antibodies to IL-4, IL-5, and IL-13 alone or in combination could be beneficial while use of anti-IFN-y may be rational in the later phase of this disease. According to the literature, anti-TNF-a therapy has, however, triggered atopic dermatitis (Mangge et al. 2003). In this case, the anti-TNF-a may have been administered during the wrong phase for such treatment. Blocking Th-2 cytokines may be beneficial in the initiation phase.

Curing Eczema Naturally

Curing Eczema Naturally

Do You Suffer From the Itching, Redness and Scaling of Chronic Eczema? If so you are not ALONE! It strikes men and women young and old! It is not just

Get My Free Ebook


Post a comment