Skin Diseases Involving Th1Th2 Cytokines

Atopic dermatitis is a disease in which Th-1 and Th-2 cytokines are involved depending on the phase of the disease. IFN-y-positive cells are predominant in the skin lesions. In the initiation phase, IL-4 production by Th-2 and Th-0 cells is predominant over IFN-y production by Th-1 cells, while in the late and chronic phase, the situation is reversed with IFN-y production dominant over IL-4, IL-5, and IL-13 production by Th-2 and Th-0 cells (Thepen et al. 1996). Thus, in the initiation phase, antibodies to IL-4, IL-5, and IL-13 alone or in combination could be beneficial while use of anti-IFN-y may be rational in the later phase of this disease. According to the literature, anti-TNF-a therapy has, however, triggered atopic dermatitis (Mangge et al. 2003). In this case, the anti-TNF-a may have been administered during the wrong phase for such treatment. Blocking Th-2 cytokines may be beneficial in the initiation phase.

Curing Eczema Naturally

Curing Eczema Naturally

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