Inhibition of IFNy as a Method of Treatment of Various Autoimmune Diseases Including Skin Diseases

B. Skurkovich, S. Skurkovich

1.1 Introduction 2

1.2 Treatment of Th-1-Mediated Autoimmune Diseases 4

1.2.1 Rheumatoid Arthritis 5

1.2.2 Multiple Sclerosis 5

1.2.3 Corneal Transplant Rejection 6

1.2.4 Type I Diabetes 6

1.2.5 Uveitis 7

1.3 Treatment of Th-1-Mediated Autoimmune Skin Diseases

Using Anti-IFN-y 7

1.3.1 Psoriasis Vulgaris 7

1.3.2 Alopecia Areata 9

1.3.3 Vitiligo 10

1.3.4 Acne Vulgaris 11

1.3.5 Herpes Simplex Virus Type 1 11

1.4 Genetic Skin Diseases in Which Cytokines

May Be Involved 12

1.4.1 Dystrophic Epidermolysis Bullosa (DEB) 12

1.5 Other Th-1-Mediated Skin Diseases in Which Testing of Anticytokine Therapy Is Warranted 13

1.6 Beneficial Effect of Anti-IFN-y in Possibly Non-Th-1-Mediated Skin Diseases 14

1.6.1 Herpes Simplex Virus Type 2 14

1.7 Skin Diseases Involving Th-1/Th-2 Cytokines

1.8 Discussion

References

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