Info

Apoptosis pathway

Caspases

Fig. 3. TNF mediates its effects through activation of NF-kB, AP-1, JNK, p38 MAPK, p44/p42 MAPK, and AKT

Fig. 3. TNF mediates its effects through activation of NF-kB, AP-1, JNK, p38 MAPK, p44/p42 MAPK, and AKT

Potential strategies to suppress TNF production and signaling through inhibition of NF-kB activation

Natural products

Natural products

NOP; NEMO oligomerization peptide

Fig. 4. Potential strategies to suppress TNF production and signaling through inhibition of NF-kB activation

NOP; NEMO oligomerization peptide

Fig. 4. Potential strategies to suppress TNF production and signaling through inhibition of NF-kB activation ubiquitination, inhibitors of the protein kinase that phosphorylates IiBa (IKK), inhibitors of IKK activation (Fig. 5), decoy peptides of IKK and p65, antisense oligonucleotides, and Si RNA to p65. These inhibitors, although quite effective in suppressing NF-kB activation, have shown limited promise in the treatment of the disease for a variety of reasons. These include in vivo toxicity, lack of specificity, and poor bioavailability. Thus safer and efficacious blockers of TNF-induced NF-kB activation are needed. Our laboratory has described numerous agents derived from natural sources that can suppress NF-kB activation induced by TNF quite effectively. Through suppression of NF-kB, these inhibitors can also suppress expression of TNF. These polyphenols (e.g., curcumin, a diferuloylmethane) have been tested in animals and found to exhibit good activity in suppression of tumorigenesis, Alzheimer disease, diabetes, arthritis, Crohn's disease, and cardiovascular disease.

Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

Get My Free Ebook


Post a comment