Il4

T-bet

Gata-3

Fig. 1. Regulation of effector T cell and Treg cell differentiation by TGFß. TGFß prevents Th1 and Th2 cell differentiation through inhibition of T-bet and GATA-3 expression. TGFß induces the expression of Foxp3 gene and promotes Treg cell differentiation

References

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Green EA, Gorelik L, McGregor CM et al (2003) CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes. Proc Natl Acad Sci U S A 100:10878-10883

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Shull MM, Ormsby I, Kier AB et al (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359(6397):693-699

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