TNF blockade has provided substantial advances in therapeutic options and pathogenetic insight in psoriasis. Novel cytokine entities offer further clinical utility to address remaining unmet clinical need, either as single agents or in potential immune modulatory combinations. IL-15 is expressed in psoriatic skin and when targeted in vivo provides substantial improvement in skin inflammation. Antibodies that target IL-15 are in phase II clinical trials in RA and are under consideration in other inflammatory conditions. This therapy offers not only amelioration of inflammatory activity but also potential effects on T cell memory that may provide the potential for promoting immune tolerance in due course. This represents the ultimate goal of current immune modulatory strategies in the treatment of autoimmune diseases. Innovative trial designs will be required to test the latter possibility.

Natural Treatments For Psoriasis

Natural Treatments For Psoriasis

Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.

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