Beneficial Effect of AntiIFNy in Possibly NonTh1Mediated Skin Diseases

1.6.1 Herpes Simplex Virus Type 2

IFN is generally known to prevent viral replication. Recurrent herpes simplex virus type 2 genital lesions, on the other hand, may be a special case in which dysregulated production of IFN-y appears to exert a pathological effect on the organism by paradoxically helping the virus survive or replicate (Singh et al. 2003). We have proposed that some viruses may belong to a special category in which IFNs or TNF-a production is dys-regulated, and in some cases these cytokines may help sustain the virus (Skurkovich et al. 1987). In this category may belong oncogenic viruses, the HIV, rubella virus, papillomavirus, possibly certain other viruses and bacteria, and some chemical agents. Herpes simplex virus type 2 may also belong in this class. IFN-y may also directly damage cells in this disease. Thus, removal of IFN-y, TNF-a, or IL-1 may help destroy the viruses or other agents sustained by these cytokines and ameliorate the condition. We have very preliminary positive data from the topical application of anti-IFN-y in a patient with a herpes simplex virus type 2 lesion. Pain was immediately relieved upon application of the antibody, and the skin began to quickly epithelialize. Further studies using anti-IFN-y need to be undertaken to confirm this very preliminary finding and in addition to test topical use of antibodies to TNF-a and IL-1 in different combinations in this condition. Parenteral and oral administration of a special form of the preparation should also be tested.

0 0

Post a comment