IL15 in Psoriasis and Psoriatic Arthritis

IL-15 exhibits a plausible bioactivity profile in skin inflammation and has been detected in high levels in a range of inflammatory dermatoses. Thus, keratinocytes express both IL-15 and IL-15Ra, suggesting a role in autocrine regulation of keratinocytes in dermal inflammatory responses (Ruckert et al. 2000). Dermal IL-15 is upregulated by UVB irradiation and overexpression is associated with cutaneous malignancy (Mohamadzadeh et al. 1995). IL-15 has also been reported in bullous lesions,...