Stop Rosacea Naturally

Rosacea Free Forever Cure By Laura Taylor

Rosacea Free Forever was written by a former rosacea sufferer who suffered this condition for over 12 years. The book will show you how Laura Taylor cured her rosacea forever in just three days in the natural way and helped thousands of rosacea sufferers do the same. There are many food products that are quite useful to reduce the flush and skin eruptions occurred by Rosacea. Besides, removing such skin diseases, such foods act as anti-aging agents and help human beings to heal from many pains of joints. This is only due to nutrients during these natural food products. So, it is recommended that try to get proper awareness about fruits and food items that plays a vital role to clean this skin dilemma. I have spent such a long time researching and experimenting with Rosacea treatments. The techniques in Rosacea Free Forever DO work and if you spent a little time trying to implement everything then you will find relief from your Rosacea. Read more here...

Rosacea Free Forever Overview


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My Rosacea Free Forever Review

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The author has done a thorough research even about the obscure and minor details related to the subject area. And also facts weren’t just dumped, but presented in an interesting manner.

As a whole, this e-book contains everything you need to know about this subject. I would recommend it as a guide for beginners as well as experts and everyone in between.

Systemic Lupus Erythematosus

The most obvious lesions of the head and neck that can be seen in SLE are those involving the skin. The most characteristic dermatologic feature of lupus is the malar rash (Fig. 1). Also known as the butterfly rash, because of its shape across the cheeks and bridge of the nose, the malar rash is an erythematous and edematous eruption that classically spares the nasolabial folds. A similar rash may be seen on the forehead and chin. It may or may not result from exposure to sunlight, but is often abrupt in onset and can last for days. Malar rashes occur in 30 to 60 of patients. Discoid lupus (Fig. 2) is less frequent, occurring in 15 to 30 of patients. It too may occur in a malar distribution however, discoid lesions can occur anywhere on the face or scalp, in the pinnae, behind the ears, or on the neck. Discoid lesions tend to be discrete plaques, often erythematous with an adherent scale that extends into hair follicles. They can progress to lesions with indurated margins of erythema...

FIGURE 1 Linear gingival erythema Source Courtesy of the International AIDS SocietyUSA From Refs 3 4

Also known as HIV gingivitis, a fiery red linear discoloration of the gingival margin can be seen in HIV disease, even without significant plaque formation (Fig. 1). Patients complain of spontaneous bleeding or are asymptomatic. Referral to an HIV dental specialist is recommended and usually involves debridement, local care, and systemic antibiotics.

Plate Iv Skin Alterations Related To Vascularization Paleness Hyperemia Telangiectasia

Women Doctors Switerland The 1800s

Plate IVB Linear telangiectasia on the medial surface of the auricle, corresponding to Chinese fengxi (Wind Stream) area on the lateral surface in a 38-year-old female who had been suffering from hay fever for several years. Plate IVB Linear telangiectasia on the medial surface of the auricle, corresponding to Chinese fengxi (Wind Stream) area on the lateral surface in a 38-year-old female who had been suffering from hay fever for several years. Plate IVC Telangiectasia and spots on the upper branch of the anthelix in a 37-year-old male suffering with the after-effects of fracture of the right tibia that occurred 8 years previously. A further spot is visible on the concha. Plate IVD Reticular telangiectasia on the scapha and a more pronounced telangiectasia on the upper branch of the anthelix in a 75-year-old male suffering with chronic degenerative gonarthritis. Plate IVC Telangiectasia and spots on the upper branch of the anthelix in a 37-year-old male suffering with the...

Plate Iii Skin Alterations Related To Vascularization Paleness Hyperemia Telangiectasia

Otic Eczema

Plate IIIA Telangiectasia on the upper branch of the anthelix, caudally delimiting an area of paleness, in a 40-year-old female with a 12 month history of carpal tunnel syndrome on the right side. A reticular telangiectasia located on the representation of the elbow is possibly associated with the patient's respiratory allergy. Plates IIIC and IIID Telangiectasia and spots on the lower border of the right ear lobe where two descending creases are going to meet together (C) paleness of the corresponding part of the left ear lobe (D) in a 66-year-old female affected by glaucoma and hypertensive retinopathy. Plates IIIC and IIID Telangiectasia and spots on the lower border of the right ear lobe where two descending creases are going to meet together (C) paleness of the corresponding part of the left ear lobe (D) in a 66-year-old female affected by glaucoma and hypertensive retinopathy.

Plate V Skin Alterations Related To Vascularization Paleness Hyperemia Telangiectasia

Reticular Telangiectasia

Plate VA Linear telangiectasia on the right upper concha, delimiting a hypertrophic area of the root of the helix, in a 65-year-old female with chronic persisting hepatitis. Plate VA Linear telangiectasia on the right upper concha, delimiting a hypertrophic area of the root of the helix, in a 65-year-old female with chronic persisting hepatitis. Plate VC Reticular telangiectasia on the left lower concha in a 66-year-old male who had undergone coronary artery bypass surgery. Plate VB Linear telangiectasia on the concha in an 18-year-old female with dyspepsia caused prevalently by lactose intolerance. Plate VB Linear telangiectasia on the concha in an 18-year-old female with dyspepsia caused prevalently by lactose intolerance. Plate VD Reticular telangiectasia on the anthelix in chronic backache due to previous vertebral fracture of L1. Another reticular telangiectasia is appreciable on the upper and lower concha as an expression of anxiety with prevalent somatization on the digestive...

Plate Vi Skin Alterations Related To Vascularization Paleness Hyperemia Telangiectasia

Plate VIB Multiple linear telangiectasia on the upper concha and hyperemia of the anthelix, both aligned on the same sectors, in a 70-year-old female affected by primary carcinoma of the liver. An angioma is furthermore visible on the upper part of the helix. Plates VIC and VID Telangiectasia on the upper concha and pigmentation of the root of the helix in a 65-year-old female affected by diabetes mellitus treated with oral hypoglycemic drugs (C). The worsening of the patient's hyperglycemia 1 year later was accompanied by a darkening of the pigmented area, a higher evidentiation of telangiectasia on the upper concha and by the appearance of a new telangiectasia on the anthelix (D). Plates VIC and VID Telangiectasia on the upper concha and pigmentation of the root of the helix in a 65-year-old female affected by diabetes mellitus treated with oral hypoglycemic drugs (C). The worsening of the patient's hyperglycemia 1 year later was accompanied by a darkening of the pigmented area, a...

Erythema Multiforme

EM is an acute, widely distributed hypersensitivity reaction associated with circulating immune complexes that are deposited in the basement membranes of the superficial vessels of the skin and mucosa. Subsequent complement activation produces vasculitis and thrombosis, leading to tissue ischemia and necrosis of the adjacent epithelium. The intensity of the skin and mucosal reaction varies from a localized minimal erythematous FIGURE 40 Erythema multiforme. Young adult male with rapid onset of generalized oral ulceration accompanied by typical target lesions of the skin. Note the hemor-rhagic, encrusted lips, a feature frequently seen in erythema multiforme. FIGURE 40 Erythema multiforme. Young adult male with rapid onset of generalized oral ulceration accompanied by typical target lesions of the skin. Note the hemor-rhagic, encrusted lips, a feature frequently seen in erythema multiforme. response to frank epithelial necrosis. Commonly identified precipitating factors include...

Differential Diagnosis

Multiple diseases can present with findings similar to those seen with Adamantiades-Behget's disease and should be considered when a patient presents with recurrent oral or genital ulcers, inflammatory eye disease, or other manifestations of vasculitis. Included in the differential diagnosis are systemic lupus erythematosus (Chapter 1), seronegative spondyloarthropathies, inflammatory bowel disease (Crohn's or ulcerative colitis) (Chapter 20), herpes or other viral infections (Chapter 10), other forms of vasculitis (Chapter 8), and inflammatory skin diseases such as pemphigus vulgaris or pemphigoid lesions (Chapter 37). All patients presenting with oral and genital ulcerations should undergo testing for herpes simplex virus using culture or polymerase chain reaction methods, to ensure that viral infection is not present. Erythema nodosum observed by a physician or patient, pseudofolliculitis, or papulopustular lesions aFindings applicable only in the absence of other clinical...

Clinical Manifestations

For patients with IK alone, the most common ocular complaints are pain, redness, and photophobia. Other eye symptoms may include excessive tearing, foreign body sensations, and blurry vision. Conjunctivitis, anterior uveitis, episcleritis, scleritis, and retinal vasculitis may be accompanied by eye pain, redness, photophobia, or reduced visual acuity. Acute angle glaucoma and proptosis have also been described in a few cases. The ophthalmological findings of IK may be relatively mild and evanescent and may consist of faint, peripheral, subepithelial corneal infiltrates. These lesions are similar to those of keratitis caused by adenovirus and chlamydia. The corneal lesions can evolve to a patchy granular infiltrate, localized predominately in the posterior cornea. The cornea can later vascularize and opacify with persistent inflammation, although such opacities occur in less than 5 of adequately treated patients.

Complications And Prognosis

While sarcoidosis frequently pursues an unpredictable clinical course, its prognosis may correlate with specific types of disease onset and patterns of clinical manifestations. For example, acute onset of erythema nodosum with symptomatic bilateral hilar adenopathy usually has a self-limited course, while insidious onset of disease and extrapulmonary lesions are often followed by inexorable progression of pulmonary fibrosis (30). In the head and neck, complications of sarcoidosis include hearing loss, vestibular dysfunction, chronic sinusitis, infection, decreased visual acuity and blindness, hoarseness, upper respiratory obstruction, stridor, cranial nerve palsies, and pituitary dysfunction. The complications of the persistent ocular inflammation are described above, but it should be emphasized that sarcoidosis is a significant cause of blindness in the United States.

Vector DNA Metabolism

Evidence that DNA repair and recombination are directly involved in circularization or concatamerization of AAV vector genomes is supported by recent insights into possible biochemical mechanisms of their formation (178,180). In fibro-blasts from a patient with ataxia telangiectasia (ATM), there is greatly enhanced formation of AAV vector circular forms and enhanced integration of the head-to-tail concatemers as proviral genomes (181). The ATM gene is a PI-3 kinase that regulates the p53-dependent cell-cycle checkpoint and apop-totic pathways, and in these ATM cells the DNA double-strand break (DSB) repair systems that normally can be activated by UV irradiation appear to be already activated maximally.

Head and Neck Manifestations

Ocular inflammation affects 20 to 25 at disease onset and 50 to 65 during the disease course. Conjunctivitis, episcleritis, and scleritis are the most common manifestations (23). Nongranulomatous uveitis and keratitis can also occur and parallel other disease activities. Other eye manifestations include periorbital edema, chemosis, tarsitis, and proptosis from posterior choroiditis or a mucosa-associated lymphoid tissue (MALT) type lymphoma. Rarely, retinal vasculitis, retinal detachment, retinal artery or vein occlusion,

TABLE 1 Clinical Manifestations in Wegeners Granulomatosis

Consequently, patients frequently suffer from recurrent infections. Collapse of the nasal bridge (saddle nose deformity) may occur due to nasal chondritis (Fig. 2). Nasal examination typically reveals crusting, discharge, friable erythematous mucosa, and granulation tissue. Nasal septum perforation may occur. The paranasal sinuses, most commonly the maxillary and ethmoid sinuses, are affected in at least two-thirds of patients. In time, many patients develop pansinusitis. Inflammation of sinus mucosa and epithelium may result in discharge, obstruction, increased pressure, facial pain, headache, and secondary infection. Chronic inflammation usually produces sinuses lined by scar tissue and airspace obliteration. Mastoiditis may result in severe pain. Regional extension of sinus disease may lead to intracranial complications such as meningitis, epidural and subdural empyema, or cerebral abscess. Orbital complications may arise de novo or be a complication of...

FIGURE 2 Wegeners granulomatosis saddle nose deformity

Ocular involvement may become apparent as eye or orbit pain, visual impairment, diplopia, episcleritis, scleritis, conjunctivitis, uveitis, retinitis, and dacrocystitis. Proptosis due to orbital pseudotumor is present in approximately 15 of cases and is the cause of pain, diplopia, and or visual loss. Pseudotumor may cause vision loss in approximately 50 of patients that present with this complication (Fig. 5) (7).

Systemic Manifestations

Facial lesions due to conditions associated with TB have been described these include erythema induratum of Bazin, papulonecrotic tuberculids, and others. M. tuberculosis DNA has been detected in erythema induratum skin lesions by PCR, and erythema nodosum has been attributed to primary TB. Skin involvement may result from exogenous inoculation, spread from an adjacent focus to the overlying skin, or hematogenous spread, often seen in patients with AIDS and tuberculous bacteremia. Any unexplained skin lesion, particularly one with nodular or ulcerative components, may be due to TB, especially in AIDS patients and biopsy and cultures are warranted.

Idiopathic Inflammatory Bowel Disease Crohns Disease

Crohn's disease is a chronic inflammatory disorder that can affect any part of the gastrointestinal tract involvement of the small bowel may be referred to as Crohn's enteritis. Crohn's disease is comparatively more common in North America and Europe which have the highest incidence the disease is relatively rare elsewhere, particularly in developing countries. To put it in context of all causes of enteropathy, recent data suggests the incidence of all childhood and adolescent Crohn's disease in northern hemisphere countries is estimated to be 2-3.7 cases per 100,000. The cause of Crohn's disease has not been defined, although the pathogenesis is complex involving an interrelation between genetic predisposition and environmental factors (fig. 2). The intestinal manifestations reflect the anatomic site of involvement, with Crohn's enteritis manifested in various combinations as diarrhea, fever, occult or gross blood in the stool, abdominal pain, aphthous ulcers, weight loss and...

Extraintestinal manifestations in Crohns disease

Extra-intestinal manifestations of IBD occur in approximately 15 of all Crohn's disease patients but in up to 30 of those with colonic disease (Jewell 2000b). The extraintestinal features present in Crohn's disease are similar to those experienced in ulcerative colitis. They include erythema nodosum, peripheral arthritis and ocular lesions. Less commonly (< 5 ), patients report pyoderma gangrenosum, primary sclerosing cholangitis, renal complications and anky-losing spondylitis.

Protection Against Uvinduced Photodamage

Oral ingestion Increasing lycopene intake to 16 mg day (using tomato paste) over a 10-week period has been shown to provide significant protection against erythema formation following UV irradiation, compared with placebo (Stahl & Sies 2002). The protective effects appear to develop slowly, as tests conducted at 4 weeks found no significant changes. Protective effects were also seen in another study that compared the synthetic lycopene with concentrated tomato extract (Lyc-o-mato) (Aust et al 2005). The daily dose of lycopene was approximately 10 mg day, which was lower in than the previous study. Again, 12 weeks were required to detect significant protective effects against UV-induced erythema and the effect was more pronounced in the group using a natural lycopene source.

Allergic rhinosinusitis

The diagnosis of allergic rhinosinusitis is based first upon clinical presentation. Thus, the presence of itchy watery eyes, sneezing, palatal itching, clear watery rhinorrhea, and sinus facial pressure suggest this disorder. In addition, the presence of other allergic manifestations such as asthma, eczema, or urticaria angioedema, and a family history of atopic disorders, provide further support. Exacerbation of symptoms during specific seasons of the year (spring trees, late spring to early summer grasses, and fall weeds and molds), or with certain exposures (e.g., cat), is additional evidence of an allergic etiology. Physical examination may be relatively unremarkable or may reveal pale and swollen nasal mucosa, sometimes described as a bluish discoloration, enlarged turbinates, and copious nasal secretions. Profound erythema of the mucosa and or the presence of purulent nasal discharge should suggest other diagnoses or the presence of complications of underlying allergic disease....

Gastrooesophageal reflux disease

Reflux oesophagitis can be detected at endoscopy, but over half of patients with true GORD will not have evidence of mucosal breaks (erosions). Oesophageal erythema or the presence of a hiatal hernia are unreliable signs that cannot be used to determine if a patient has reflux disease. Although some patients are unable to adequately describe their symptoms or decide which is their predominant complaint, if a detailed history is taken a clinical diagnosis of GORD can be made in most cases, including those in whom endoscopy is normal.

Diagnosis And Treatment The Infectious Etiologies

Infections in Immunocompromised Individuals. A special type of external otitis is termed malignant otitis externa. This is a bacterial otitis externa present in diabetic or immunocompromised patients in whom there is osteomyelitis of the skull base. The disorder is caused by Pseudomonas aeruginosa infection and may be recognized by granulation tissue in the external ear. The ear also may present with significant inflammation and erythema (12). A culture of the ear positive for Pseudomonas does not make the diagnosis, since Pseudomonas is part of the flora of a normal ear and can also be positive in simple otitis externa. The best diagnostic test is a bone scan looking for evidence of the osteomyelitis. It is important for clinicians to keep a high index of suspicion for this disorder, since, if not treated appropriately, the disorder can progress to lateral sinus thrombosis, involvement of the temporal mandibular joint (TMJ), multiple cranial nerve involvement, and meningitis (13,14).

Homeopathic medicine

A homeopathic practitioner will take a full medical history, paying particular attention to the onset and progression of rosacea and its possible triggers, followed by an examination of affected areas. Many remedies are suitable for the constitutional treatment of symptoms of rosacea (see page 18), but prescription will depend upon the individual. Among the remedies often chosen are Carbo veg., for when blood stagnates in capillaries, resulting in poor oxygen supply to facial tissue and Lachesis for hemorrhaging that allows infection to set in. Psorinum is prescribed for problems of the sebaceous glands and Rhus tox. is given for infection such as that forming boils. Homeopathic remedies prescribed for acute symptoms include Belladonna, for the early stages of rosacea, when the face is red, dry, and burning hot and Arsen. alb., when the skin is flaky and scaly, there is restlessness, and the condition is better for warmth generally as well as for warm compresses applied to the...

Assessment Of Oral Mucosa

The face is observed for fullness suggestive of salivary gland enlargement. Speech is assessed for the smacking sound of the dry oral mucosa sticking to the teeth. The lips are observed for dryness, fissuring, erythema, ulceration, and swelling. The mouth is examined starting with the labial mucosa, the buccal mucosa, the hard soft palate, the gingiva, the tongue, and the floor of mouth. A piece of gauze is used to dry the floor of the mouth to determine whether pooling occurs as saliva exits the submandibular sublingual glands. Bimanual palpation of the submandibular sublingual glands is used to determine if swelling is present. Saliva is assessed as it is expressed from the right and left parotid papillae, where it exits from Stenson's duct into the oral cavity. The quality of the saliva is noted as clear, cloudy, or thickened, along with the presence or absence of pain sensitivity with the saliva milking process. Typically saliva exiting the parotid glands will disperse...

Clinical manifestation

Majority of the patients with glucagonomas present with a dermatitis called necrolytic migratory erythema, causing pruritis and often becoming secondarily infected (Perry and Vinik, 1995). The clinical manifestation may also include diabetes, depression and deep vein thrombosis. Glucagonomas are frequently found in the pancreatic tail and have a malignant potential with a predilection for metastases. A serum glucagon level > 500 pg ml is highly suspicious of the diagnosis, whereas, a concentration of > 10,000 pg ml is virtually diagnostic (Chastain, 2001). However, a normal level does not exclude the diagnosis as secretion of glucagon may be episodic and a high concentration may be seen in other clinical syndromes such as sepsis, renal and hepatic failure. Initial management with somatostatin analogues are usually very effective in controlling symptoms however, such treatment may not have an effect on tumor growth. (Jockenhovel et al., 1994) Diabetes, necrotizing migratory...

Relapsing Polychondritis

Relapsing polychondritis is discussed in detail in Chapter 7. It is a chronic multisystem inflammation of cartilage (9). It may affect all types of cartilage including elastic cartilage of ears and nose, hyaline cartilage of joints, and tracheobronchial cartilage. About one-half of patients have airway involvement. The female-to-male ratio is 3 1. Peak onset is in the fourth to fifth decades. It occurs predominantly in Caucasians but occasionally in other races. Relapsing polychondritis can also affect other tissues such as the eyes, blood vessels, heart, and inner ear. It most often presents with sudden onset of auricular pain and erythema that spare the lobule, accompanied by fever and lethargy. Acute episodes resolve within 5 to 10 days, but recurrent bouts of inflammation are common, with progressive permanent destruction of the cartilage (Fig. 4).

Indications Other Viburnums

Abortion (f FEL HH3) Ague (f DEM) Alcoholism (f FEL) Ameba (f WOI) Amenorrhea (f FEL) Arthrosis (f TOM) Asthma (f1 APA EFS FAD HOC VAD) Bleeding (f FEL) Blepharosis (f VAD) Cancer (f JLH) Cardiopathy (f FEL) Childbirth (f DAW) Chorea (f FEL) Colic (f FEL) Congestion (f FEL) Conjunctivosis (f VAD) Convulsions (f DEM) Corneal Abrasians (f VAD) Cramp (f1 APA DEM EFS FAD FEL) Dermatosis (f1 APA FEL LAF PNC VAD) Dropsy (f DAW) Dysentery (f FEL) Dysmenorrhea (f1 APA FAD HH3 LAF PH2 TOM VAD) Eczema (f1 VAD) Fever (f1 APA) Enterosis (f1 APA) Epilepsy (f FEL) Erythema (f VAD) Female Ails (f DEM) Fever (f DAW) Glossosis (f DEM) Headache (f1 APA) Hemorrhoid (f1 VAD) Hiccup (f FEL) High Blood Pressure (f1 VAD) Hot Flash (f TOM) Hysteria (f EFS FEL TOM) Infection (f DAW) Inflammation (f FEL VAD) Insomnia (f1 APA EFS FAD) Intermittent Claudication (f FEL JAD) Itch (f VAD) Jaundice (f FEL) Lethargy (f LAF) Malaria (f DAW) Menorrhagia (f FEL) Miscarriage (f APA FAD LAF) Ophthalmia (f BUR FEL) Pain...

Dermatological Conditions

Sunburn protection Topical application of 1 alpha-tocopherol provided significant protection against erythema and sunburn in an experimental model. When combined with 1 5 ascorbic acid, the protective effect was enhanced (Lin et al 2003). Further improvements were seen when ferulic acid was added to the alpha-tocopherol (1 ) and ascorbic acid (15 ) solution, as this substance improves chemical stability of the antioxidants and doubles the photoprotective effect (Lin et al 2005). Although most research has focused on topical use, oral administration of a combination of high-dose vitamin E and C increases the threshold to erythema. The first study to show that the systemic administration of vitamins C and E reduces the sunburn reaction in humans was a small double-blind placebo-controlled trial that used ascorbic acid (2 g day) combined with D-alpha-tocopherol (1000 lU day) (Eberlein-Konig et al 1998). The effect was seen after 8 days. The next was a 50-day study of 40 volunteers (20-47...

Diagnosis And Treatment

FIGURE 6 Matted telangiectasias on the lip of a patient with hereditary hemorrhagic telangiectasia. Courtesy of Dr. Terence O'Grady, University of California San Diego. FIGURE 6 Matted telangiectasias on the lip of a patient with hereditary hemorrhagic telangiectasia. Courtesy of Dr. Terence O'Grady, University of California San Diego.

Case examples and scoring sheets

The patient, a 27-year-old woman, was admitted to the department of gastroenterology for the evaluation of diarrhea. There are several reasons for the admission. First, in the last month extensive diagnostic evaluations have been made, but a final diagnosis is still to be determined. Second, the patient's condition has declined, and she has lost about 10 kg in the last month. Third, the patient has informed her doctor that she is almost incapable of doing anything at home. She has suffered from systemic lupus erythematosus (SLE) for about 4 years and is being treated by a nephrolo-gist, because her kidneys were the primary location of the disease. There is a gradual decline of the kidney function. A relationship between the diarrhea and the SLE is expected but has not yet been confirmed. During the admission the following information is obtained. Although the patient is silent during the admission process, she starts to cry when the nurse suggests that she must have been in an awful...

Cytokine Gene Transfer into Autologous Tumor Cells

Groups from Vienna, Freiburg, and Wurzburg performed a phase I trial to evaluate the safety and tolerability of repeated skin injections of IL-2-transfected autologous melanoma cells into patients with advanced disease using a transferrin-me-diated and adenovirus-enhanced transfection system (114). Fifteen patients received 2 to 8 skin vaccinations of either 3 x 106 (intradermal) or 1 x 107 (half intradermal, half subcutaneous) transfected melanoma cells per vaccination (secreting 140 to 17,060 biological response modifier program units of IL-2 106 cells 24 h). Overall, the vaccine was well tolerated. All patients displayed modest local reactions (erythema, induration, and pruritus) and some experienced flulike symptoms. Apart from newly appearing (4 of 14) and increasing (5 of 14) antiadenovirus and newly detectable antinuclear antibody titers (1 of 15), recipients developed de novo or exhibited increased melanoma cell-specific delayed-type hyper-sensitivity (DTH) reactions (8 of 15)...

Cytokine Gene Transfer into Allogeneic Tumor Cells

Obtaining sufficient number of autologous tumor cells for genetic manipulation is sometime problematic and is time consuming. Therefore, several studies have used well-characterized, allogeneic melanoma cell lines or fibroblasts as vehicles for cytokine delivery. Arienti et al. (115) and Belli et al. (116) first vaccinated 12 melanoma patients with 5 or 15 x 107 IL-2-gene-modified allogeneic melanoma cells. Three of 8 patients assessable experienced an MR. Two patients showed increased reactivity of specific CTL directed against tyrosi-nase and gp100 melanoma-associated antigens in postvaccination peripheral blood lymphocytes (PBL). Two additional patients showed an increased frequency of melanoma-specific CTLp in postvaccination PBL. The same group, in a subsequent study (117), tested IL-4-gene-transduced allogeneic melanoma cells in successive vaccinations in 12 melanoma patients. Both local and systemic toxicities were mild, consisting of transient fever and erythema, swelling and...

Localized Scleroderma

Localized scleroderma (morphea or linear scleroderma) involves the skin and subcutaneous tissue in one area, although there may be involvement of other organ systems. Presentation tends to be indolent, starting with superficial erythema of the skin that gradually spreads. There may be central clearing with a lilac ring appearance. With time, there is hardening of the skin or subdermal structures, leading to an ivory-like appearance of the tissue (95). Loss of hair and anhydrosis is common along with hypo-pigmentation or hyperpigmentation. Involvement of the deeper structures varies. Classification of localized scleroderma is based on clinical morphological findings and the depth of tissue involved (96,97). The terms localized scleroderma and morphea have often been used interchangeably, leading to confusion. Morphea is used by most rheuma-tologists to describe a subgroup of localized scleroderma that presents with oval-shaped patches or plaques characterized by thickening and...

The Chinese Contribution To The Inspection Of The Outer

It is interesting to recall the different stages in the Chinese experience the first was the confirmation of the ear's somatotopic representation of the different anatomical parts of the body through inspection, for example deformation or cartilaginous hypertrophy of the inferior crus of the anthe-lix in case of lumbar spondylosis or prolapsed intervertebral disk. Next came the proof that acupuncture treatment of dyschromia, telangiectasia, etc. within the somatotopic area related to a patient's disease gave good results. Then came the pien-cheng sih chih method with the global consideration of the ear according to TCM. The last fascinating and at the same time complex stage was to obtain elements, through auricular inspection, for eventually revealing a suspected hidden tumor. our countries to find scars from chilblains. Tenderness at pressure of a skin alteration is, however, fundamental for diagnosis and may be used to treat symptoms. For example, acupuncture on a sensitive...

Plate Xi Skin Alterations Related To Pigmentation Dyschromia Macula Nevus

Medial Surface Ear

Plates XIA and XIB Multiple asymmetrical nevi on the right and left auricle in a 45-year-old male carrying a diagnosis of obsessive-compulsive disorder. Besides the particular concentration of nevi on the ear lobes, to be noted are linear telangiectasia on the right Shen men, liver and knee areas (A) on the left to be noted are a hypertrophy of the stomach area and linear telangiectasia on the anthelix and on the heart area of the left lower concha (B).

Classification Of Skin Alterations Of The Outer

Telangiectasia - reticular telangiectasia - punctiform telangiectasia - linear telangiectasia correspond to 42.6 of the total followed by pigmented skin alterations (mainly nevi and maculae) corresponding to 26.2 skin alterations of skin structure (creases and incisures) correspond to 15 . The remaining three groups follow with percentages below 5-10 (Fig. 4.4). The six categories of skin alteration have a different distribution on the 11 areas of the auricle. Telangiectasia are mostly seen on the anthelix, nevi prevalently on the helix followed by the ear lobe. Maculae have a uniform distribution on the anthelix, helix and lobe. The skin alterations of sebaceous gland structure (particularly comedones) were found mainly on the cymba conchae followed by the cavum conchae. Also depressions and dyskeratosis were found mostly on the cavum conchae. Also interesting is the comparison between the different Telangiectasia The upper part of the ear shows a hyperemic area of the helix (sector...

Promotion Of Remineralization And Reversal Of The Demineralization Process

Oral Infections in patients who have salivary dysfunction tend to be primarily mucosal erythematous fungal infections, or less frequently infection of the salivary glands. Clinically, this type of fungal presents as generalized or localized patchy areas of erythema on the tongue, buccal mucosa, palate, lips, and corners of the lips. The erythema almost invariably is associated with the sensation of burning and sensitivity to spicy acidic foods. If the infection is on the tongue, depapillation (bald tongue) may be observed. With treatment, the burning sensation, depapillation of tongue, and taste alterations will resolve. If the burning sensation does not resolve with treatment, and there is an absence erythema at the site, then the presence of burning mouth

Paraneoplastic Syndromes

Dermatomyositis Dermatomyositis (DM) is an idiopathic inflammatory myopathy with characteristic cutaneous manifestations including heliotrope rash of the periorbital skin, erythematous scaly plaques on dorsal hands with periungual telangiectasia and photosensitive poikilodermatous eruption. The myopathy is generally symmetrical and slowly progressive during a period of weeks to months affecting mainly the proximal muscles and characterized by specific inflammatory lesions in muscle biopsy. It is caused by vasculitis determined by humoral factors with subsequent inflammatory cell accumulation, mainly T CD4+ and B cells, which infiltrate myocytes leading to its vacuolization and degeneration (mainly in the skeletal muscles, rarely in the smooth muscles). Lung cancer is the most common type of cancer associated with DM and among lung cancer subtypes SCLC is most frequently associated, accounting for approximately 50 .

Indications Coriander

Adenopathy (f KAB) Ameba (f PH2) Amenorrhea (f JFM) Anorexia (f2 APA EFS KOM PH2) Arthrosis (f BIB HHB) Asthenia (f BOU) Bacillus (1 HH2 X15612768) Bacteria (1 PH2 X15612768) Biliousness (f BIB DEP SUW) Bleeding (f DEP EGG PH2) BO (f APA) Bron-chosis (f KAB) Burn (f BOU) Cancer (f JLH) Cancer, abdomen (f JLH) Cancer, colon (f JLH) Cancer, sinew (f JLH) Cancer, spleen (f JLH) Cancer, uterus (f JLH) Carbuncle (f BOU DEP) Cardiopathy (f BIB GHA) Catarrh (f BIB) Chickenpox (f PH2 SKJ) Childbirth (f IHB PH2) Cholecocystosis (f PHR) Cholera (f BOU) Colic (f DEP GHA HHB) Condyloma (f JLH) Conjunctivosis (f DEP GHA) Coryza (f KAB) Cough (f IHB PHR PH2) Cramp (f1 BGB BIB PH2) Cystosis (f PH2) Dermatosis (f PHR PH2) Diabetes (f JFM) Diarrhea (f APA EGG HHB) Dysentery (f1 APA PHR PH2) Dyspepsia (f12 APA DEP GHA HHB KOM PH2) Dysuria (f PH2) Edema (f PH2) Enterosis (f2 BGB JLH PHR PH2) Epistaxis (f EGG PH2) Erotomania (f BIB) Erysipelas (f BIB) Erythema (f DEP) Escherichia (1 HH2 X15612768) Fever...

Indications Caper Bush

Adenopathy (f BIB JLH) Aging (f BIB) Allergy (1 X15799005) Amenorrhea (f DEP) Arteriosclerosis (f BIB BOU) Arthrosis (f BIB) Bleeding (f BOW) Cancer (f1 BIB) Cancer, abdomen (f1 FNF JLH) Cancer, bladder (f1 FNF JLH) Cancer, colon (f1 FNF JLH) Cancer, groin (f1 FNF JLH) Cancer, head (f1 FNF JLH) Cancer, kidney (f1 FNF JLH) Cancer, liver (f1 FNF JLH) Cancer, neck (f1 FNF JLH) Cancer, spleen (f1 FNF JLH) Cancer, uterus (f1 FNF JLH) Cataract (f BIB) Chill (f BIB BOU) Cirrhosis (f WO2) Cold (f BIB) Conjunctivosis (f BOW) Cough (f BOW GHA) Cramp (1 HOS) Cystosis (f JLH) Dengue (f BIB HJP) Diabetes (f GHA) Diarrhea (f BOW BOU) Dropsy (f BIB BOU DEP) Dysentery (f BIB) Dysmenorrhea (f BIB) Earache (f BI2 GHA) Enterosis (f BOW) Erythema (1 X15799005) Fever (f BOU) Fracture (f BIB) Ganglion (f BOU) Gastrosis (f BOW GHA) Gout (f DEP SKJ WO2) Headache (f BIB) Hepatosis (f1 JLH HOS WO2) Hyperacidity (f MKK) Impotence (f BOU) Induration (f JLH) Infection (f BOW BOU) Infertility (f BIB BOU)...

Ruta graveolens L Rutaceae Herb of Grace Common

Adverse Reactions Hypotension, hypersensitivity, rash, erythema and blisters may occur when applied topically. 26 Therapeutic dosages could bring about melancholic moods, sleep disorders, tiredness, dizziness and spasms. 27 Misuse as an abortive during pregnancy can lead to vomiting, epigastric pain, kidney damage, depression, sleep disorders, feelings of vertigo, delirium, fainting, tremor, spasm and sometimes may end up with fatal outcome. 8

Methodology Of Inspection

There are, however, differences in the distribution of skin alterations which do not depend on different histological patterns of the skin or a different nervous supply. In these cases other factors may be involved such as the representation on each auricular portion of specific anatomical structures of the body. For example it is very interesting to see how variable the ratio is between the vascular and pigmentary skin alterations on the different parts of the ear which have the same innervation the ratio is 3.6 for the anthelix 1.4 for the medial surface 1.1 for the antitragus 0.7 for the helix 0.5 for the ear lobe. These differences make sense if we look at the topography of skin alterations the skeletal apparatus with its muscles is represented on the anthelix and the medial surface of the ear. Therefore if hyperemia or telangiectasia are found on these parts it is reasonable to suspect a chronic or recurrent disorder of the locomotor system (see Plates IIA and IVA and IVD).

Plate Ix Skin Alterations Related To Pigmentation Dyschromia Macula Nevus

Plate IXB Multiple spots on the anthelix at the bifurcation into upper and lower branch in a 42-year-old male affected by congenital hip displacement. At least two telangiectasia are visible on the anthelix. Plate IXB Multiple spots on the anthelix at the bifurcation into upper and lower branch in a 42-year-old male affected by congenital hip displacement. At least two telangiectasia are visible on the anthelix. Plate IXD Spots and telangiectasia on the fossa triangularis and the upper branch of the anthelix on the left auricle. Aligned with these alterations and point zero are two nevi on the helix. The 41-year-old female had been operated on for a ovarian cyst on the left side and suffered with recurrent cystitis her other symptoms were backache, migraine and asthma.

Medium Vessel Vasculitis

The peak age-of-onsetis at one year of age and 80 to 85 of cases occur at less than five years of age. Kawasaki disease (KD) is defined by the presence of fever persisting for at least five days, together with the presence of at least four of the following changes of extremities (acute erythema of palms, soles oedema of hands, feet, and subacute periungual peeling of fingers, toes in weeks 2 and 3) polymorphous exanthema bilateral bulbar conjunctival injection without exudates changes in lip and oral cavity erythema, lips cracking, strawberry tongue, diffuse injection oral and pharyngeal mucosae cervical lymphadenopathy (30). Initial treatment is with aspirin and intravenous immunoglobulin and further management is determined by the presence of coronary artery involvement, occurring in 20 to 30 of untreated cases. Although rare in adolescents, it does occur, and may be associated with more cardiovascular morbidity due to late presentation (30).

Enhance Wound Healing

Topical use Bepanthen is a well-known dermatological preparation containing dexpanthenol, an alcoholic analogue of pantothenic acid. It has been investigated in numerous studies and found to act like a moisturiser, activate fibroblast proliferation, accelerate re-epithelialisation in wound healing, have anti-inflammatory activity against UV-induced erythema and reduce itch (Ebner et al 2002). Under double-blind study conditions, epidermal wounds treated with dexpanthenol emulsion showed a reduction in erythema, and more elastic and solid tissue regeneration. Another randomised, prospective, double-blind, placebo-controlled study published in 2003 investigated the efficacy of topical dexpanthenol as a skin protectant against irritation. The study involved 25 healthy volunteers who were treated with a topical preparation containing 5 dexpanthenol or placebo and then exposed to sodium lauryl sulphate 2 twice daily over 26 days. Treatment with topical dexpanthenol provided protection...

Literature review Individual TrxG genes 31 ASH2L

The acetyltransferase MOF (males absent on the first) associates with MENIN, MLL or MLL2, and the core COMPASS proteins (ASH2L, DPY30, HCF1, RBBP5, and WDR5) to form a distinct TrxG complex 90 . MOF specifically acetylates H4K16, a HPTM linked to transcriptional activation 91 . In cancer cells, loss of H4K16ac represents a common event and correlates with general hypomethylation of repetitive DNA sequences 92 . This suggests that MOF activity is inhibited in cancer cells and that MOF therefore functions as an oncosuppressor. Many important growth-regulatory pathways are regulated by MOF, some of which do not require the H3K4 methyltransferase ability of COMPASS-like complexes. First of all, MOF inhibits cancer progression by cooperating with forkhead box protein P3 (FOXP3) 93 . FOXP3 recruits MOF and the H3K4 methyltrasferase complex close to the transcription start site of tumor suppressors 93 . The synergistic effect of H3K4 trimethyla-tion by MLL1-2 and of H4K16 acetylation by MOF...

Viral infections of the skin

Herpes simplex is normally found on the face and around the lips. It begins as an itching sensation, followed by erythema and a group of small blisters which then weep and form crusts. This condition will generally persist for approximately two or three weeks but will reappear at times of stress, ill health or exposure to sunlight. This is a painful infection along the sensory nerves due to the virus that causes chickenpox. Lesions resemble herpes simplex with erythema and blisters along the lines of the nerves. The areas affected are mostly on the back or upper chest wall. This condition is very painful due to acute inflammation of one or more of the peripheral nerves. Severe pain may persist at the site of shingles for months or even years after the apparent healing of the skin.

Plate Xiv Skin Alterations Related To Cartilaginous Structure Hypertrophy ie Thickening Hypotrophy ie Depression

Plate XIVA Hypertrophy and telangiectasia on the root of the helix in a 62-year-old male suffering with gastroduodenitis associated with Helicobacter pylori infection. Plate XIVA Hypertrophy and telangiectasia on the root of the helix in a 62-year-old male suffering with gastroduodenitis associated with Helicobacter pylori infection.

Neurocutaneous syndromes

Neurocutaneous syndromes A group of genetic neurological skin disorders affecting the brain, spine, and peripheral nerves that can cause tumors to grow inside the brain, spinal cord, organs, skin, and skeletal bones. The most common syndromes involving children include neurofibromatosis, sturge-weber syndrome, tuberous sclerosis, ataxia-telangiectasia, and von hippel-lindau disease.

Mucous Membrane Pemphigoid

FIGURE 30 Lichenoid stomatitis in chronic hepatitis C. This red and white lesion at a high-risk site like the lateral border of the tongue was sensitive to spicy food and was highly suspicious for a premalignancy. A biopsy showed a liche-noid mucositis without dysplasia. Note the central erythematous area surrounded by white, radiating striae, the typical lichenoid clinical appearance. Source Courtesy of Stacy Mullins, DDS. FIGURE 30 Lichenoid stomatitis in chronic hepatitis C. This red and white lesion at a high-risk site like the lateral border of the tongue was sensitive to spicy food and was highly suspicious for a premalignancy. A biopsy showed a liche-noid mucositis without dysplasia. Note the central erythematous area surrounded by white, radiating striae, the typical lichenoid clinical appearance. Source Courtesy of Stacy Mullins, DDS. FIGURE 32 Desquamative gingivitis in mucous membrane pemphigoid. Note the gingival erythema and erosion. Desquamative gingivitis is a clinical...

Select the points corresponding to one or more syndromes described by TCM

Identified with ESRT, four points were selected the Shen men point and heart area to calm the spirit and to 'regulate the deficit of qi and blood of the Heart'. The spleen point and the neck muscles point of the medial surface were selected to 'strengthen the spleen and the stomach' for dyspepsia and to reduce muscular tension. It is noteworthy that the heart area was identifiable at inspection and was covered by a reticular telangiectasia the Shen men area moreover was identifiable by a telangiectasia nearby the point identified with ESRT.

Treatment of Th1Mediated Autoimmune Skin Diseases Using AntiIFNy

We used anti-IFN-y in patients with psoriasis vulgaris, alopecia areata, vitiligo, acne vulgaris, and herpes simplex type 1, and plan to expand the trials using a humanized monoclonal antibody. Trials are also planned for testing the treatment in other Th-1-mediated skin diseases, including seborrheic dermatitis, rosacea, oral lichen planus, and dermatophyto-sis, which are discussed in the following sections. In most cases, we used two methods of delivery of the antibody intradermal injection around the lesion and intramuscular administration. Thus, anti-IFN-y delivered to the lesion either IM or locally brought the same effect. We believe anticytokine therapy, particularly the removal or inhibition of IFN-y and or TNF-a and IL-1, may be a rational treatment for many severe autoimmune skin diseases that do not respond to standard therapies. We first proposed that anticytokine therapy could be beneficial in treating psoriasis in 1977 (Skurkovich et al. 1977). Recently in an open-label...

Inflammatory Autoimmune

Pemphigus is a rare disease that affects mucosal membranes. Although the term pemphigus may be erroneously used interchangeably with the condition bullous pemphigoid, it is a separate entity warranting a separate discussion. Pemphigus is characterized by vesicular lesions and bulla. There are multiple subtypes, with pemphigus vulgaris and pemphigus foliaceus being the most common (7). Other subtypes include pemphigus vegetans, pemphigus erythematosus, pemphigus herpetiformis, paraneoplastic pemphigus, drug-induced pemphigus, and IgA pemphigus. Although it is a disease of all ages, it typically occurs between the ages of 30 and 60. Pemphigus affects males and females equally. There is no known ethnic predilection. Its pathogenesis stems from an autoimmune mechanism in which circulating antibodies target keratinocyte cell surfaces. Cell-to-cell adhesion is disrupted and antibody complexes activate the complement cascade, creating local tissue damage. The cause of this...

Candidate Diseases For Cutaneous Gene Therapy

The autosomal recessive ich-thyoses are a clinically heterogeneous family of diseases characterized by abnormal cornification, and comprise LI and congenital ichthyosiform erythroderma (114). In LI, patients are born encased in a ''collodian'' membrane that is later shed and followed by development of large, thick scales of varying degrees of erythema. Palmar and plantar hyperkeratoses are often present.

Stevensjohnson syndrome

SJS is one clinical presentation of a severe cutaneous drug reaction. Experts in the field utilize a classification in which erythema multiforme (EM), SJS, and toxic epidermal necrolysis (TEN) represent severity variants of the same process (28,29). EM-minor is usually self-limited and caused by infections. Drug-induced EM, termed EM-major, can progress into SJS or, when very severe, TEN. SJS is a bullous disorder, with ulceration, purpura, fever, and involvement of mucous membranes in more than two locations, as well as the skin. TEN is used to describe more severe SJS-like disease, with sloughing of the skin resembling a third-degree burn.

Plate Vii Skin Alterations Related To Vascularization Angioma

Plate VIID Angioma allocated within a reticular telangiectasia on the upper branch of the anthelix in a 73-year-old male further punctiform angioma on the tail of the helix and some incisures are visible on the upper part of the helix. When the picture was taken, the first angioma was related to the patient's prostate adenoma 4 years later unfortunately a further diagnosis of cancer of the rectum was made.

Sweet Leaf Bush Cekup Manis Daun Katuk

Daun Katuk

Made from the juice of the fresh leaves and honey, and applied to the tongue and gums cures thrush of the tongue in infants. The leaves are used for erythema, measles and dysuria. Its roots serve as a diuretic and relieve congestion. 4 The root decoction is used for fever and urinary bladder complaints. 11

Rhinocerebral Mucormycosis

Schwartz noted that these nerve abnormalities are often consistent with orbital apex syndrome (unilateral ptosis, proptosis, visual loss, complete ophthalmoplegia, and ophthalmic and maxillary nerve anesthesia and anhidrosis) (11). Most cases of orbital apex syndrome are due to mucormycosis or Aspergillus, and visual loss is usually irreversible. In contrast with typical bacterial orbital cellulitis, patients with RCM may have minimal preseptal lid erythema, more pain in the forehead or temple than in the eye, and early onset of decreased sensation in the first and second divisions of cranial nerve V. The facial edema associated with RCM may be confused with periorbital cellulitis. The periorbital edema described for RCM is soft, cool, and nontender, differentiating it from the warm, tender, taut edema of cellulitis (9). Mucormycosis can be further distinguished from cellulitis by examining the character of the ptosis, if present RCM produces a paralytic ptosis in which the eyelid can...

Other Th1Mediated Skin Diseases in Which Testing of Anticytokine Therapy Is Warranted

Other skin diseases that appear to involve a Th-1-mediated immune response include seborrheic dermatitis (SD), rosacea, oral lichen planus, and dermatophytosis. SD has upregulated expression of proinflamma-tory cytokines in skin biopsies of SD lesions (Molinero et al. 2003). T-cell subsets are also found in the dermal infiltrates of rosacea lesions (Rufli and Buchner 1984), and IFN-y-producing cells are found in dermatophytosis (Koga et al. 2001). In oral lichen planus, mononuclear cells express IFN-y in the superficial lamina propria (Khan et al. 2003). Our near-term goal is to test anticytokine therapy in these conditions.

Skin lesions disorders and diseases

Rosacea this is a chronic inflammatory condition found on the face. The skin is flushed and red due to dilation of blood vessels, and appears coarse with enlarged pores. Papules and pustules may develop. It is thought to be caused by intolerance to certain food or drink or over-exposure to extremes of climate. Tea, coffee or alcohol may exacerbate the condition as will exposure to sun and wind. These clients will usually be under medical supervision if they are not, suggest medical referral. Do not massage over the area.

The Topography Of The Identified Auricular Pointarea

Figure 9.3 shows the right ear of a 64-year-old male patient who asked to be treated with acupuncture because he suffered with recurrent backache, especially on the right side. The inspection of the right auricle did indeed show a little hyperemia of the anthelix corresponding to the thoracolumbar junction and some telangiectasia on the representation of the Chinese knee. My attention was attracted, however, by a linear telangiectasia crossing the liver area. PPT identified two tender points on it which were furthermore aligned with point Fig. 9.3 Tender points on a telangiectasia of the upper concha in a 64-year-old male patient carrying a hepatic steatosis due to excessive drinking.

Patterns of Clinical Presentation

The spine should be examined for painful scoliosis and a left curve, findings that are often associated with a tumor. Paravertebral muscle spasms, a rigid spine, and spinal point tenderness are seen with tumor and infection, but can also be associated with mechanical etiologies (spondylolysis and disk herniation). A waddling gait with flexed knees indicates spinal nerve root irritation, which can occur with tumors, disk herniation, spondylolisthesis, or intervertebral disk disease. In contrast, a bizarre gait, with prancing steps or other non-organic pattern of walking, is suggestive of a psychogenic problem. If a spinal cord problem is suspected, reflexes, including of the abdomen and anus, and strength and sensory testing should be done. Tenderness of the sacroiliac joints, spine tenderness in a broad area, and decreased lumbar flexibility are findings associated with JIA patients are also likely to have peripheral joint arthritis and enthesitis or other findings such as dactylitis...

Infectious Diseases Mycobacterial Infection

In contrast, patients with atypical cervical mycobacterial infection present with isolated lymphadenitis involving submandibular and submental groups (Fig. 1). These patients almost never present with constitutional symptoms. Affected nodes may become densely adherent to the subcutaneous and cutaneous tissues, resulting in skin necrosis manifested by erythema and fluctuance (Fig. 2).


In a controlled study injection of phytoene, the colourless triene precursor of beta-carotene was found to significantly reduce radiation-induced erythema in guinea pigs (Mathews-Roth & Pathak 1975) however, a further study on albino hairless mice found that 10 g kg feed of beta-carotene and 200 mg kg feed of 13-c s retinoic acid for 12 weeks did not prevent UVB-induced dermal damage (Kligman & MathewsRoth 1990).

Genetic factors

Persons with extra chromosomes (genetic material contained in cells) or certain chromosomal abnormalities have a greater chance of developing leukemia. Children with Down syndrome, neurofibromatosis type 1 (NF1), Shwachman syndrome, Bloom syndrome, Franconi anemia, Kostmann syndrome, and ataxia telangiectasia have a higher risk of getting leukemia than do children without these genetic disorders. However, most children with these syndromes do not develop leukemia.


The previous study determined that apigenin exerts the strongest anti-inflammatory action, which is ten times greater than matricin, which is ten times greater than chamazulene (Delia Loggia et al 1990). Another study evaluated the effects of apigenin on the lipopolysaccharide-induced pro-inflammatory cytokines IL6 and TNF-alpha in vitro and in vivo (Smolinski & Pestka 2003). Apigenin reduced IL6, but not TNF-alpha in vitro. Pretreatment with the flavone (50 mg kg) reduced IL6 by 35 and TNF-alpha by 33 in vivo as compared with control animals. Alpha-bisabolol has demonstrated anti-inflammatory and analgesic effects in a number of experimental inflammatory models rat paw oedema, adjuvant arthritis of the rat, ultraviolet erythema of the guinea pig, and yeast fever of the rat (Jakovlev et al 1979).

Indications Aloe

WO3) Epilepsy (f KAP) Erysipelas (f CRC EGG) Erythema (f12 X15857459) Escherichia (1 NP9(2) 8) Fever (f DEP GHA VOD NP9(2) 8) Flu (1 NP9(2) 8) Fracture (1 RCP7(1)) Frostbite (f12 APA PH2 WHO NP9(2) 8) Fungus (1 AAB APA MPI PH2) Gastrosis (f CRC VOD WO3) Gingivosis (f WO3) Glaucoma (f WHO) Glioma (1 X15747063) Glossosis (f JLH) Gonorrhea (f JFM) Headache (f GHA VOD) Hemorrhoid (f APA CRC WHO) Hepatosis (f1 BEJ CRC DEP RCP6(1)) Herpes (12 AAB PH2 NP9(2) 8 RCP7(1)) High Cholesterol (1 WO3 X14598919) High Triglycerides (1 JAC7 405) HIV (1 WO3) Hysteria (f CRC VOD) IBD (12 X15043514) Immune Deficiency (1 CAN PNC) Impotence (f NP9(2) 8) Indigestion (1 WAM) Infection (f1 APA BEJ PH2 NP9(2) 8) Infertility (1 CRC MPI) Inflammation (f1 CAN CRC GHA PH2 VOD WHO NP9(2) 8 X15182910) Intoxication (1 X8937458) Ischemia (1 PH2) Itch (f DAA) Jaundice (f CRC KAB) Klebsiella (1 NP9(2) 8) Leprosy (f KAB) Leukemia (f CRC JLH) Leukorrhea (f JFM) Lumbago (f KAB) Measles (1 NP9(2) 8) Mouth Sores (f1 CAN EGG)...

Blood vessels

The amount of blood flowing near the surface of the skin is controlled by nerve endings in the artery walls. If the body is becoming too hot, the small arteries dilate (get bigger). This causes flushing of the skin known as erythema and the body loses heat via the skin. If the body becomes too cool the arteries constrict, preventing heat loss. Massage stimulates the nerve endings and by reflex action the blood vessels dilate producing an erythema.

Acute gastritis

This may involve the gastric body and antrum of the stomach and is often erosive and haemorrhagic. The response of the gastric mucosa to trauma is similar to that in other tissues with the release of an array of physiologically active substances. Erythema and oedema are predominant features.


In evaluating a child with a spondyloarthropathy who has gastrointestinal complaints, testing for the antibody pANCA may speed recognition of the child with IBD. Either of two skin findings, erythema nodosum (large, tender, painful, red or purplish bumps over the shins) or pyoderma gangrenosum (large areas of skin breakdown with weeping sores), in a child with a spondyloarthropathy should spark careful consideration for possible IBD. Many of the children with arthritis and IBD are HLA B27-positive. Children with IBD who are HLA B27 positive are more likely to have significant and persistent arthritis than those who are HLA B27 negative. In addition to IBD, children who have abdominal pain, rash, and arthritis might have reactive arthritis, Henoch-Schoenlein purpura, Kawasaki disease, polyarteritis nodosa, dermatomyositis, systemic lupus erythematosus, or other vasculitic diseases, among other possible conditions. Most often the correct diagnosis is evident, but I have seen children...

Physical Examination

The skin is dry and has a peculiar bluish erythema over the knuckles and knees. Orange-yellow discoloration of the skin (carotinodermia), seen in palms and soles, is frequently found. It is caused, at least in part, by an increased intake of vegetables, since it may also be seen among vegetarians.


Among the newly identified mutations in this comprehensive study, Y471X, R151S, L709R, and K695N were observed as pathogenic reflecting the typical FMF character involving abdominal pain, fever, thoracic pain, myalgia, arthritis, and erysipelas like erythema. Rare mutations and SNPs have great importance for FMF pathogenesis. For this periodic fever disorder, heterogeneity is present in phases of allelic, frequency and critical locations of mutant alleles, and clinical appearance. Therefore, in particular for the suspicious cases possible presence of other autoinflammatory disease gene mutations as we outlined above and rare mutations and SNP variations in the MEFV gene, molecular techniques, sample sizes, ethnic origins, and regions in the ancestral countries should be regarded as critical and determinative keys in FMF clinical and molecular diagnosis.

Ulcerative colitis

Abdominal pain is not a prominent symptom for most patients with ulcerative colitis, but mild colicky pain or lower abdominal discomfort relieved by defaecation may be present in some patients. In severe disease, patients can present with fever, weight loss, malaise and lethargy. Weight loss is largely due to diminished food intake secondary to anorexia. Systemic features of anaemia, such as shortness of breath and ankle swelling, may also be present. Extra-intestinal manifestations of ulcerative colitis affect 10-20 of patients these include primary sclerosing cholangitis, erythema nodosum, pyoderma gangrenosum, iritis and arthritis (Jewell 2000a).


Angioedema (Fig. 1) is the abrupt and transient swelling of the skin, mucous membranes, or both, including the upper respiratory and intestinal epithelial linings (11). In some cases, angioedema and urticaria should be viewed as varying manifestations of the same pathologic process, and they are common components of anaphylactic reactions. Angioedema involves the reticular dermis and subcutaneous or submucosal tissue, particularly of acral areas, while urticaria involves the papillary dermis and mid-dermis throughout the body. The depth of involvement will result in different clinical presentations. Urticarial lesions are erythema-tous, short lived (< 24 hours) and intensely pruritic, while the swelling of angioedema is nonpitting, pink or skin colored, more persistent and described as burning, stretching, or painful, rather than pruritic.

Autoimmune Diseases

Cogan's syndrome (Chapter 6) is a rare disease characterized by nonsyphilitic interstitial keratitis associated with vertigo, tinnitus, and hearing loss (21). If the same labyrinthine complaints are associated with other forms of ocular inflammation (e.g., uveitis and episcleritis), the condition is known as atypical Cogan's disease. The auditory and vestibular dysfunction resembles that seen in Meniere's disease and, untreated, progresses to profound deafness within weeks or months. The interval between ocular and otologic disease varies from a few weeks to a year either organ may be affected first. The etiology of Cogan's syndrome is unknown. While the relatively focal inflammation suggests organ-specific autoimmunity, this has not been proven. Like other vasculitides, the disease may represent a hypersensitive immune reaction to a viral infection. The systemic vasculitides may involve the labyrinth. Wegener's granulomatosis (Chapter 8) is a systemic vasculitis of medium and small...

Lyme Disease

Lyme disease, also termed Bannwarth's syndrome, is caused by an infection with the spirochete Borrelia burgdorferi transmitted by tick bites. It is a systemic disease affecting the skin, nervous system, heart, and joints. Symptoms may be mild and can include fever, fatigue, migratory arthritis, myalgia, headache, meningismus, lymphadenopathy, and skin lesions. Erythema migrans, a characteristic skin lesion found in Lyme disease, is defined as an enlarging, annular erythematous skin lesion seen in half of infected patients (2).


Psoriasis A double-blind placebo-controlled study found topical aloe vera extract 0.5 in a hydrophilic cream to be beneficial in the treatment of psoriasis. Sixty patients aged 18-50 years with slight to moderate chronic psoriasis and PASI (psoriasis area and severity index) scores between 4.8 and 16.7 (mean 9.3) participated in the study, which was scheduled for 16 weeks with 12 months of follow-up. Patients were examined on a weekly basis and those showing a progressive reduction of lesions, desquamation followed by decreased erythema, infiltration and lowered PASI score were considered healed. By the end of the study, the aloe vera extract cream had cured 83.3 of patients compared with the placebo cure rate of 6.6 (P < 0.001). Psoriatic plaques decreased in 82.8 of patients versus only 7.7


Use horse chestnut for Horse chestnut is a leading herbal treatment for weakened veins, including varicose veins, hemorrhoids, acne rosacea, and chronic venous insufficiency (CVI). It has an unusual capacity to strengthen small blood vessel walls by reducing the size and number of the pores it also works well on wrinkles by tightening the skin (an alternative to Botox, perhaps ), and for fluid retention or edema.

Indications Nettle

Boil (f NPM) BPH (root) (12 BGB KOM MAB PH2 NP9(2) 10) Bronchosis (f1 CRC MAB PED) Bug bites (1 MAB) Burns (f1 BGB CRC MAB) Cachexia (f KAB) Calculus (f CRC) Cancer (f CRC FAD) Cancer, breast (f1 CRC JLH) Cancer, ear (f1 CRC JLH) Cancer, feet (f1 JLH) Cancer, lung (f1 CRC JLH) Cancer, mouth (f1 CRC JLH) Cancer, prostate (f1 NP9(2) 10 X15254411) Cancer, rib (f JLH) Cancer, spleen (f1 CRC JLH) Cancer, stomach (f1 CRC JLH) Cancer, womb (f1 CRC JLH) Cardiopathy (f AAH) Carcinoma (f BIB) Caries (f NPM) Catarrh (f WOI) Childbirth (f DEM) Cholangitis (f CRC) Cholecystosis (f CRC FAD MAB WOI) Cholera (f FEL) Cold (f AAH CEB NPM) Colic (f CRC) Colitis (f FEL MAB) Congestion (f APA) Constipation (f CRC WOI) Consumption (f1 BUR MAB SUW) Corn (f AAH) Cough (f AAH NPM) Cramp (f AAH MAD) CVI (1 BGB) Cystosis (f FEL) Dandruff (f PH2 WOI) Dermatosis (f1 BGB CAN MAB FT74 677) Diabetes (f1 CRC MAD PH2 FT74 677 EB49 406) Diarrhea (f1 BGB BUR FAD FEL MAB) Dislocation (f NPM) Dropsy (f AAH BGB CRC)...

Head and Neck

Swollen, nodular, or erythematous scalp arteries Erythema, facial swelling, facial pain, and ischemic changes with Vascular and Skin. Thickening, pulselessness, pain with palpation, and the appearance of painful nodules of the affected arteries occur typically in the temporal artery but also may occur in other branches of the external carotid artery, particularly the facial, maxillary, occipital, and posterior auricular arteries (Fig. 1). Typical skin changes include erythema and local or generalized facial swelling and pain. Soft-tissue swelling may occur, particularly in the periorbital and cheek areas. Ischemic changes and necrosis of the skin may occur and may even lead to local bone destruction, but this is rare, since the temporal artery generally has good collateral formation (Fig. 2). Biopsies of the affected skin generally reveal nonspecific inflammatory changes or endarteritic obliterative changes.

Dermatological Uses

Similar results have been obtained for topical vitamin C preparations in several animal models (Darr et al 1992, 1996, Lin et al 2003) and a small human study (Keller & Fenske 1998). The latter study found that application of an aqueous 10 l-ascorbic acid solution produced a significant reduction in the minimal erythema dose and a less intense erythematous response than controls after UVB radiation.


In children, juvenile polyps account for approximately 90 of colonic polyps. They can be classified as hamartomatous or inflammatory and are also commonly referred to as retention polyps. Grossly, they are large (up to 3 cm), mostly pedunculated, erythematous, and friable. Fluid-filled cysts on the surface can be appreciated endoscopically microscopically, this corresponds to dilated, mucous-laden cystic glands and some inflammatory cells (Figure 2). Endoscopy and histology Pseudomembranes (mucin, fibrin, polymorphonuclear lymphocytes, necrotic debris) Erythema Edema Friability Apthous ulcers Treatment Supportive therapy Cessation of offending antibiotic Metronidazole as first-line agent Vancomycin secondary agent Probiotics useful in relapse


Stomatitis refers to an inflammatory process involving the mucous membrane of the mouth that may manifest itself through a variety of signs and symptoms including erythema, vesiculation, bulla formation, desquamation, sloughing, ulceration, pseudomembrane formation, and associated discomfort. Stomatitis may arise due to factors that may be of either local, isolated conditions or of systemic origin. For example, a solitary oral ulcer with a history of a recurrent pattern may be classified as recurrent aphthous stomatitis, a purely local phenomenon. Another clinically-similar-appearing lesion, on the other hand, may represent an oral mucosal manifestation of a more generalized disease process such as Crohn's disease. Stomatitis may involve any site in the oral cavity, including the vermillion of the lips, labial buccal mucosa, dorsal ventral tongue, floor of mouth and hard soft palate, and gingivae. The differential diagnosis of stomatitis is challenging because the inflammatory...


As an ancestral population of FMF, Turkey was one of the regions which involves most of the rare and novel mutations. As referenced in INVEFERS, most of the rare mutations in view of the ethnic origins were found to be symptomatic. Novel Y471X mutation found in the present study was the second nonsense mutation in FMF era. Among the newly identified mutations, involving R151S, S166N, S179N, and G340R P350R, G456A, Y471X, S503C, I506V, L709R and K695N Y471X, R151S, L709R, and K695N were observed as pathogenic reflecting the typical FMF character. The main clinical characteristics of the patients were as follows abdominal pain (92.1 ), fever (93.9 ), thoracic pain (59 ), myalgia (67.8 ), arthritis (55.1 ), erysipelas like erythema (ELE) (21.8 ). None of the patients developed amyloidosis. This finding verifies the importance of molecular diagnosis and detailed sequencing which is recommended to perform in particular for the ancestral populations of FMF.

Pernicious Anemia

A similar clinical appearance of the tongue mucosa may be seen in Vitamin B complex deficiencies and iron deficiency anemia (Fig. 44), which are also frequently associated with angular cheilitis. Since both Vitamin B12 and folate deficiencies exhibit macrocytic hyperchromic anemia, it is necessary to perform serum folate and B12 determinations in order to distinguish between them. Atrophic candidiasis (Fig. 45) may also produce a sensitive, erythematous, depapillated lingual mucosal surface. FIGURE 46 Central papillary atrophy. Also referred to as median rhomboid glossitis, this was long believed to be a developmental condition. It is now recognized as a form of erythematous candidiasis appearing as a well-demarcated zone of erythema in the midline of the dorsal tongue with a smooth or lobulated surface. The lesion is typically asymptomatic and frequently resolves with antifungal therapy.

Active immunotherapy

In 24 Patients with resected pancreatic cancer, with K-ras mutations at codon 12, were vaccinated once monthly for 3 months with a 21-mer peptide vaccine containing the corresponding K-ras mutation of the patient's tumor. Immune responses were evaluated by delayed-type hypersensitivity (DTH) tests and the enzyme-linked immunosorbent spot assays. Results showed there were no grade 3-5 vaccine-specific toxicities. The only National Cancer Institute grade 1 and 2 toxicity was erythema at the injection site (94 ). Nine patients (25 ) were evaluable for immunologic responses. One patient (11 ) had a detectable immune response specific to the patient's K-ras mutation, as assessed by DTH. Three patients (13 ) displayed a DTH response that was not specific. Median recurrence free survival time was 8. 6 months (95 confidence interval, 2.96-19.2) and median overall survival time was 20. 3 months (95 confidence interval, 11.6-45.3). It suggested K-ras vaccination for patients with resectable...

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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