PSADT and Survival of prostate cancer patients

The importance of PSA-DT in predicting survival is illustrated by Freedland et al. [41] Figure 5. This chart presents data for a group of patients experiencing biochemical recurrence of PSA after prostatectomy. Under these circumstances, PSA-DT clearly defined prostate cancer survival into four groups: 1) PSA-DT >=15 months, 2) PSA-DT 9-14 months 3) PSA-DT 3-8.9 months, 4) PSA-DT <3 months. For this study, PSA-DT is clearly a surrogate for prostate cancer-specific survival.

Fifteen-year Actuarial Kaplan-Meier Prostate Cancer-specific Survival Curves by PSADT

PSADT*3mo

Time after biochemical recurrence (years)

PSADT*3mo

Time after biochemical recurrence (years)

5096 patient with prostate adenocarcinoma who had undergone radical prostatectomy al the Johns Hopkins Hospital from April 1982 tc October 2000 with follow-up data available During a mean (SO] of {4 4) years and median fallow-jp pi 5 years, 973 (19%) developed a biochemical recurrence, defined as a single postoperative PSA of at leasl 0.2 ng/mL, This study included patients with at least 2 PSA values separated by at least 3 months within 2 years alter biochemical recurrence who did not receive adjuvant radiation or hormonal therapy prior to biochemical recurrence (n-411). Palients who received preoperative radiation (n=2) or hormonal therapy (n - 10) were excluded. Modified from Freedland el. at. JAMA. July 27. 2005-Vol 294, No. 4 p 433

Figure 5.

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