"Advances in Prostate Cancer" is an addition to the InTech collection of three previous books about prostate cancer and aims at providing a comprehensive overview of specific aspects of the latest research and current knowledge relating to this tumor entity to scientists and clinicians. For this purpose a series of research articles, clinical investigations and reviews that deal with a wide range of relevant aspects pertinent to the epidemiology, diagnosis, patient care, treatment and basic biology of prostate cancer were included. Thereby this book aptly adds to the other InTech titles in the field of oncology, that describe advances in cancer therapy, diagnosis and treatment of various cancers with reference to the cancer stem cell concept.

The numerous participating authors of this book shared their expertise in epidemiology and etiology, as well as supportive care, which comprises the handling of psychological challenges and effects of physiotherapy in coping with the consequences of prostate cancer treatment. State-of-the-art radiation therapy is moreover discussed as well as the significance of testosterone and PSA measurements, the latter in form of a novel internet "App" that helps to interpret the time course of the marker determinations on the outcome. After many years of limited means to treat advanced prostate cancer several new agents such as CYP17 inhibitors and new cytotoxic drugs, as well as a cancer vaccine, became available, which poses new questions in regard to patient selection and appropriate choice of medical care. These topics comprehensively discussed in several chapters are supplemented by a review of the current state of intermittent androgen suppression versus continuous hormone ablation. These chapters are complemented by a number of discussions on the some characteristics of the cell biology of prostate cancer, including cancer stem cells, inflammatory processes, roles of androgen receptor and diverse non-androgen gene transcripts and, furthermore, cell adhesion proteins. This book is therefore destined to all cancer researchers and therapists who intend to understand the current status of cell biology and treatment of prostate cancer.

As editor of this book, I would like to acknowledge the significant efforts made by all of the contributing authors for their excellent work as well as the entire Intech editorial team in publishing of this volume. I would like to dedicate this book to the "Ludwig Boltzmann Society" and, in particular, to Prof. Dr. Gerhard Baumgartner whose long-standing support has allowed for the successful realization of many scientific projects. Last but not least, I would like to thank my wife for her personal support and great patience at all times.

Gerhard Hamilton, PhD

Ludwig Boltzmann Cluster of Translational Oncology

Section 1

Epidemiology and Etiology

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