Other steroidal inhibitors

Other reported steroidal inhibitors of CYP17 are depicted on figure 8. The 17-aza derivative 94 inhibited human CYP17 with an IC50 value of 4.9 |jM [123]. Compound 95 inhibited both 5a-reductase and CYP17 with k values of 27 and 14 nM, respectively [124]. The oxime 96 was also a dual inhibitor with the ability to reduce serum and prostatic T and DHT concentrations in vivo [125].

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