Contents

Section 1

Chapter 1

Chapter 2

Section 2

Chapter 3

Chapter 4

Section 3

Chapter 5

Chapter 6

Preface IX

Epidemiology and Etiology 1

Epidemiology of Prostate Cancer 3

Martin Dörr, Anne Schlesinger-Raab and Jutta Engel

Is There an Infectious Agent Behind Prostate Cancer? 19

Ugo Rovigatti

Supporitve Care 61

Psychological and Social Factors influencing Patients' Treatment Selection for Localised Prostate Cancer 63

Luke A Robles, Shihning Chou, Owen J Cole, Akhlil Hamid, Amanda Griffiths and Kavita Vedhara

The Role of Physiotherapy in the Pre and Post Treatment Interventions in Prostate Cancer Patients 79

Mario Bernardo Filho and Mauro Luis Barbosa Júnior

Surgical Care and Radiation Therapy 103

Abdominoperineal Resection: Consideration and Limitations of Prostate Cancer Screening and Prostate Biopsy 105

Zachary Klaassen, Ray S. King, Kelvin A. Moses, Rabii Madi and Martha K. Terris

Radiation Therapy for Prostate Cancer 117

Shinji Kariya

Chapter 7 High-Dose-Rate Interstitial Brachytherapy as Monotherapy in One Fraction for the Treatment of Favorable Stage Prostate Cancer 145

Pedro J. Prada

Section 4 Prostate Cancer Markers 155

Chapter 8 Testosterone Measurement and Prostate Cancer 157

Tine Hajdinjak

Chapter 9 Describing Prostate Cancer Dynamics: Second Look at PSA-Doubling Time and PSA-Specific Growth Rate 177

Glenn Tisman

Section 5 Medical Treatment 217

Chapter 10 Rational Categorization of the Pipeline of New Treatments for Advanced Cancer - Prostate Cancer as an Example 219

Sarah M. Rudman, Peter G. Harper and Christopher J. Sweeney

Chapter 11 Novel Therapeutic Settings in the Treatment of Castration-Resistant Prostate Cancer 251

Miguel Álvarez Múgica, Jesús M. Fernández Gómez, Antonio Jalón Monzón, Erasmo Miguelez García and Francisco Valle González

Chapter 12 Steroidal CYP17 Inhibitors for Prostate Cancer Treatment: From Concept to Clinic 275

Jorge A. R. Salvador, Vânia M. Moreira and Samuel M. Silvestre

Chapter 13 Intermittent Androgen Suppression Therapy for Prostate Cancer Patients: An Update 305

Gerhard Hamilton and Gerhard Theyer

Section 6 Cell Biology of Prostate Cancer 331

Chapter 14 Stem Cells and Prostate Cancer 333

Vildan Bozok Qetinta§, Burqin Tezcanli Kaymaz and Buket Kosova

Chapter 15 Salinomycin-Induced Apoptosis in Human Prostate Cancer Cells 361

Hak-Jong Choi, Kwang-Youn Kim, Sun-Nyoung Yu, Sang-Hun Kim, Sung-Sik Chun, Hak-Sun Yu, Yeong-Min Park and Soon-Cheol Ahn

Chapter 16 Natural Compounds, Antioxidant and Antiandrogens in the Prevention of Prostate Cancer: In vivo Evidences from Murine Models and Human Clinical Studies 377

Rossano Lattanzio, Alessia Lamolinara, Mauro Piantelli and Manuela Iezzi

Chapter 17 Prostate Cancer, Inflammation and Antioxidants 401

Marika Crohns, Tuomas Westermarck and Faik Atroshi

Chapter 18 Inflammatory Microenvironment in Prostate Carcinogenesis 423

Geraldine Gueron, Javier Cotignola and Elba Vazquez

Section 7 Role of Androgen Receptor 463

Chapter 19 Expression and Function of Stromal Androgen Receptor in Prostate Cancer 465

Mandeep Singh and Peng Lee

Chapter 20 Prostate Cancer Progression to Androgen Independent Disease: The Role of the PI3K/AKT Pathway 473

Jacqueline R Ha, Yu Hao D Huang, Amit Persad and Sujata Persad

Section 8 Non-Androgen Gene Transcripts in Prostate Cancer 519

Chapter 21 Non-Androgen Regulated Transcription Factors as Novel Potential Targets for Prostate Cancer Therapy 521

J. Nathan Davis, Adam H. Greer, Thomas Yong and Shari Meyers

Chapter 22 Trithorax Genes in Prostate Cancer 539

Pier-Luc Clermont, Francesco Crea and Cheryl D. Helgason

Chapter 23 The Function of YY1 and Its Oncogenic Role in Prostate Cancer 563

Daniel B. Stovall and Guangchao Sui

Chapter 24

The Role of PARP Activation in Prostate Cancer 589

Luis A. Espinoza

Section 9

Chapter 25

Cell Adhesion Proteins in Prostate Cancer 617

Integrins in Prostate Cancer Invasion and Metastasis 619

Paulynn Chin Suyin, Joanne Louise Dickinson and Adele Frances Holloway

Chapter 26

The Role of E-Cadherin-Catenin Complex in Prostate Cancer Progression 639

Anuradha K. Murali and James S. Norris

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