Conclusions

High dose rate brachytherapy as monotherapy in one fraction with a transperineal hyaluronic acid injection into the peri-rectal fat to decrease rectal toxicity for patients with favorable risk prostate cancer is feasible and very well tolerated with advantages compared to LDR and HDR brachytherapy as monotherapy using the fractionation schema of 4 fractions administered 2 times daily during two days.

HDR monotherapy in one fraction resulted in a low genitourinary morbidity and no gastrointestinal toxicity but clinical and biochemical control rates will be reported as longer follow-up.

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