Abbreviations

AR^androgen receptor COX-2^cyclooxygenase-2

CXCR4-C-X-C chemokine receptor type 4,bonzo, STRL33 or TYMSTR CXCR7-C-X-C chemokine receptortype 7, RDC1 ECM^extracellular matrix ELR^glutamic acid-leucine-arginine motif EMT^epithelial mesenchymal transition HIF-1a -^hypoxia-inducible factor 1 alpha HO-1^heme-oxygenase 1 IFNs^interferons

IGF-IR^insulin-like type I growth factor receptor

IL6^interleukin 6

IL8^interleukin 8

miRNAs or miRs^microRNAs

MMP -^matrixmetalloproteinase

MnSOD^manganesesuperoxidedismutase

NF-KB^nuclear factor kB

Nrf2^nuclear factor (erythroid-derived 2)-like 2 RNS -^reactive nitrogen species PARs^serine proteases PI3K -^phosphatidylinositol-3 kinase PIN^prostaticintraepithelial neoplasia^

Prx^peroxiredoxin

PSA -^prostate specific antigen

PTEN^phosphatase and tensin homolog

RECIST -^Response Evaluation Criteria in Solid Tumors

RNS -^reactive nitrogen species

ROS -^reactive oxygen species

SDF-1 -^stromal derived factor 1

STAT3^signal transducers and activators of transcription-3 TGFß^transforming growth factor beta

TMPRSS2-ERG -^transmembrane protease, serine 2 - ets related gene TNFa^tumor necrosis factor alpha

TRAIL -^tumor necrosis factor-related apoptosis-inducing ligand VEGF -^vascular endothelial growth factor

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