Natural Polycystic Ovary Syndrome Treatment Ebook
Women who receive treatment with valproic acid may be at higher risk of developing polycystic ovary syndrome (PCO). A Finnish study by Isojarvi et al 112 evaluated 29 women with epilepsy who were taking valproic acid monotherapy. They found that 13 29 (45 ) of the women had some form of menstrual disturbance, and 10 23 (43 ) had evidence of PCO on ultrasound. The risk was especially high in women who began treatment with valproic acid prior to age 20, with 80 having polycystic ovaries or elevated serum testosterone, a marker for PCO. Among the 12 women taking a combination of valproic acid and carbamazepine, 3 12 (25 ) had some form of menstrual disturbance, and 2 12 (17 ) had evidence of PCO. In comparison, menstrual disturbances were less likely to occur in women taking carbamazepine monotherapy (23 120, 19 ) or healthy controls (8 51, 16 ). A recent study by Rasgon et al 113 examined 10 women
Buckwheat contains D-chiro-inositol (Figure 13.3), which can lower the concentration of blood glucose in streptozotocin-diabetic rats (Kawa, Taylor, et al., 2003) and type 2 diabetic mice (KK-Ay) (Yao et al., 2008). D-chiro-Inositol can be incorporated into mammalian cells as the free form and exists in cells as inositol phosphates and inositol phospholipids. Women with polycystic ovary syndrome have insulin resistance and hyperinsulinemia, and these symptoms are considered to be due to the deficiency of D-chiro-inositol containing phosphoglycan (see Figure 13.3), which mediates the action of insulin. The administration of D-chiro-inositol increases the action of insulin in patients with polycystic ovary syndrome, improving the function of ovaries and decreasing the blood pressure and the concentrations of androgen and triacylglycerol in blood (Cheang et al., 2004 Nestler et al., 1999). These data suggest that products containing buckwheat flour may be used to treat diabetes and...
Think I am a good candidate for gastric bypass surgery What do I need to do to obtain insurance coverage for this
Ship with your primary care doctor, he or she will know about your weight loss attempts and will be treating you for any of your obesity-related illnesses or conditions (elevated cholesterol and triglycerides, gallstones, pancreatitis, abdominal hernia, fatty liver, diabetes or prediabetes, polycystic ovary syndrome, high blood pressure, heart disease, pulmonary hypertension, stroke, blood clots in the legs and lungs, sleep apnea, arthritis, gout, lower back pain, infertility, urinary incontinence, or cataracts).
I am writing to request coverage for gastric bypass surgery for my patient Ms. Donna Smith. Ms. Smith is a thirty-three-year-old woman who is 5'3 tall and weighs 295 pounds, giving her a BMI of 52. She already suffers from many obesity-related disorders including diabetes, hypertension, hyperlipidemia, and sleep apnea. She has also been diagnosed with polycystic ovary syndrome and has been unable to become pregnant. I believe all her obesity-related conditions will be markedly improved with gastric bypass surgery.
Sertoli-Leydig cell tumors (SLCTs) are rare, accounting for 0.2 of all ovarian tumors. Unlike granulosa-stromal cell tumors, they occur principally in women in the reproductive years with 75 occurring before age 40 and occurring less commonly during menopause or childhood. Similar to theca cells, SLCTs are usually hormonally active and secrete testosterone, thus resulting in androgen excess and potential virilization. In any women presenting with virilization, it is necessary to consider other etiologies including Cushing's syndrome, adrenal tumors, pituitary dysfunction, adrenal hyper-plasia, or drug-induced hyperandrogenism. On physical examination, an adnexal mass may be detectable, in conjunction with symptoms associated with androgen excess. As in other ovarian tumors, ultrasound is used for diagnosis. Imaging typically reveals a well-circumscribed unilateral solid mass, or it may reveal a heterogeneously enlarged multicystic ovary (Fig. 11-6). Diagnosis relies on a combination...
Obesity-related illnesses and conditions include elevated cholesterol and triglycerides, gallstones, pancreatitis, abdominal hernia, fatty liver, diabetes and prediabetes, polycystic ovary syndrome, high blood pressure, heart disease, pulmonary hypertension, stroke, blood clots in the legs and lungs, sleep apnea, arthritis, gout, lower back pain, infertility, urinary incontinence, and cataracts. If you have one of these conditions gastric surgery can be considered when the BMI is 35 or higher. In many cases gastric bypass surgery can dramatically improve obesity-related conditions. I have had many patients who after gastric bypass surgery were able to give up their blood pressure, diabetes, and cholesterol lowering medications. Many young women who have been unable to become pregnant conceive and go on to have healthy babies (more on this later).
Polycystic ovary syndrome Insulin resistance and hyperinsulinemia are major components of polycystic ovary syndrome (PCOS) in obese and lean adult women and in adolescent girls 101,102 . PCOS affects 5 to 10 of women in the reproductive age group and is characterized by hyperandrogenism and amenorrhea or oligomenorrhea secondary to chronic anovulation 102 . Thirty percent to 40 of women with PCOS have IGT, and 7.5 to 10 have T2DM by the fourth decade 103,104 . A recent study of screening PCOS adolescents with oral glucose tolerance test showed IGT in approximately 30 and diabetes in approximately 4 105 . Our studies revealed that insulin sensitivity is approximately 50 lower in obese adolescents who have PCOS versus matched controls 106 . Adolescents who have PCOS and IGT have 40 lower first-phase insulin secretion and lower glucose disposition index compared with adolescents with NGT 107 . The presence of this metabolic profile in the early course of PCOS significantly increases the...
How can I rationalize surgically changing my insides and risking significant complications even death just to lose
An article in the Journal of the American Medical Association (January 8, 2003) reported that marked obesity in a man aged twenty to thirty could reduce his life expectancy by up to thirteen years. An extremely obese woman in this same age range might expect to lose up to eight years compared to her normal-weight friends. These are not small numbers. People who are overweight are more likely to develop obesity-related illnesses such as heart disease, pulmonary hypertension, stroke, diabetes, sleep apnea, and arthritis. And obese people are much more likely than lean people to develop blood clots in the legs and lungs, gallstones, pancreatitis, abdominal hernia, fatty liver, polycystic ovary syndrome, high blood pressure, arthritis, gout, lower back pain, infertility, urinary incontinence, and cataracts.
Menstrual Function and Fertility Obesity in premenopausal women is associated with menstrual irregularity and amenorrhea. 112,116 As part of the Nurses' Health Study, a case control study suggested that the greater the BMI at age 18 years, even at levels lower than those considered obese, the greater the risk of subsequent ovulatory infertility. 117 The most prominent condition associated with abdominal obesity is polycystic ovarian syndrome, 118 a combination of infertility, menstrual disturbances, hirsutism, abdominal hyperandrogenism, and anovulation. This syndrome is strongly associated with hyper-insulinemia and insulin resistance. 119
Recent advances in Cr nutrition research include the demonstration of an inverse relationship between toenail Cr and cardiovascular disease (CVD) in studies from the United States and Europe, supporting studies indicating that people with CVD tend to have lower levels of serum and tissue Cr and also substantiating the beneficial effects of supplemental Cr on blood cholesterol, triglycerides, and high-density lipoprotein cholesterol. Supplemental Cr as chromium picolinate (the most common form of supplemental Cr) was shown to be effective in the treatment of depression. Preliminary studies suggest that the effects of Cr are greater than those of any drugs used in the treatment of atypical depression. Supplemental Cr is also free of side effects associated with drugs, which are often quite serious in the treatment of depression. Studies also show that Cr is beneficial in the reversal of polycystic ovarian syndrome, gestational diabetes, and steroid-induced associated with administration...
Polycystic ovary syndrome Polycystic ovarian syndrome is a reproductive disorder characterized by hyperandrogenism and chronic anovulation not caused by specific diseases of the ovaries, adrenals, and pituitary. It is one of the most common hormonal disorders in women, with a prevalence estimated between 5 and 10 53-55 . Women with the polycystic ovary syndrome are more insulin resistant than are controls 56 . In these women, insulin acts synergistically with luteinizing hormone to increase the androgen production by ovarian theca cells. Insulin also inhibits hepatic synthesis of sex hormone-binding globulin, the main carrier protein for testosterone, and increases the proportion of testosterone that circulates in the unbound, biologically available, or free, state. The sole presence of IR does not lead to diabetes and 30 to 40 of women with the polycystic ovary syndrome have impaired glucose tolerance, and as many as 10 have type 2 diabetes by their fourth decade 57,58 . This implies...
Hormone stimulation is one of the cornerstones of modern IVF, but for women with polycystic ovaries or polycystic ovarian syndrome who have many tiny follicles in their ovaries, the stimulation protocol can be difficult to manage and they risk over-responding to the drugs and developing ovarian hyperstimulation syndrome (OHSS) (see Chapter 10). Embryologists are currently perfecting a technique known as in-vitro maturation (IVM) to allow such women to have IVF without hormone stimulation. Using IVM, the doctor retrieves immature eggs from tiny follicles in the woman's ovaries and then the embryologist places these eggs in a special culture medium for a few days to allow them to mature before introducing them to the partner's sperm. So, no need for injections and no risk of OHSS sounds perfect.
But testosterone measurements are not important only for urologists, who, apart from main reason - decisions related to prostate cancer management, use it for example also for aging male symptomatology and evaluation of patients with erectile dysfunction. Also other medical specialties, like endocrinology, pediatrics, gynecology or oncology use testosterone measurements for their conditions, like diagnosing and monitoring hyper- or hypo- andro-genic disorders in women, like polycystic ovary syndrome, alopecia, acne, hirsutism or hy-poactive sexual desire disorder androgen secreting neoplasms congenital syndromes with ambiguous genitalia Pediatrics and endocrinology were in the past probably most frequent users of testosterone assays, but nowadays most laboratories receive most testosterone requests from urologists.
Secondary diabetes can result from extreme insulin resistance induced by glucocorticoids (Cushing's syndrome) growth hormone (acromegaly) adrener-gic hormones (pheochromocytoma) other medical conditions, such as uremia, hepatic cirrhosis, or polycystic ovary syndrome or medications (diuretics or exogenous glucocorticoids).
Ovaries contain follicles in various stages of development. Follicles are fluid-filled little cysts where eggs grow and mature before ovulating. Between 10 and 20 per cent of women have polycystic ovaries, an excess number of tiny follicles in their ovaries, and ovulate very infrequently and some 5 per cent of women suffer from a more severe condition, polycystic ovarian syndrome a hormone imbalance that affects many bodily functions, including ovulation.
Skin problems Intertrigo, seborrheic eczema, and thrush are common in the thick heavy skinfolds of severely obese children. Pink or pale cutaneous striae, distinct from the purplish striae resulting from thinning of subcutaneous tissues in Cushing's syndrome, are common on the abdomen and upper limbs and may be a source of embarrassment. Hirsutes (abnormal facial and body hair) occurs particularly in adolescent girls with polycystic ovarian syndrome, which is associated with obesity and insulin resistance. Acanthosis nigricans, a velvety, pigmented, thickening of the skin usually at the back of the neck, is another important marker for insulin resistance, affecting up to 90 of children with type 2 diabetes mellitus.
Polycystic ovary disease (PCOS) A metabolic disorder (also called Stein-Leventhal syndrome) in which cysts develop on a teenage girl's ovaries as the level of male hormones in her body increases. Many of these girls also develop insulin resistance. Polycystic ovary disease (PCOS) was first recognized in 1935, but doctors are not sure what causes it. The condition may be related to excess insulin production, which could signal the body to release extra male hormones. PCoS seems to have a genetic component as well. Between 6 percent and 10 percent of teenage girls have PCOS. If not treated, it can lead to infertility, excessive hair growth, ACNE, diabetes, heart disease, uterine bleeding, and cancer. Proper treatment for PCoS, however, can prevent these problems.
VLC diets have also been proven to be an effective method in jump-starting patients on conventional weight-loss treatments (Quaade and Astrup 1989). In addition, VLC diets have been shown to reduce cravings for unhealthy foods (Harvey et al. 1993 Martin et al. 2006) and improve obesity-related conditions, such as non-insulin-dependent diabetes (Capstick et al. 1997), sleep apnea and hypertension (Kansanen et al. 1998), cardiovascular disease (Ramhamadany et al. 1989), and hormonal and metabolic disorders, such as polycystic ovarian syndrome and related hirsutism (Okajima et al. 1994). Okajima, T., Koyanagi, T., Goto, M. and Kato, K. (1994) Hormonal Abnormalities Were Improved by Weight Loss Using Very Low Calorie Diet in a Patient with Polycystic Ovary Syndrome, Fukuoka Igaku Zasshi 85 (9) 263-6.
Hormonal Complications Females Obese women have normal levels of total plasma estradiol but reduced levels of sex hormone binding globulins (SHBG). Thus, free estradiol (the biological active moiety) is significantly elevated. The high levels of free estradiol are postulated to increase the risks of endometrial and breast cancer and to reduce fertility. Estrone, derived in adipose tissue from androgen precursors, is also increased in obesity. Obesity in women is associated with the polycystic ovary syndrome (PCOS), characterized by hyper-estrogenism, hyperandrogenism, polycystic ovaries, oligomenorrhea or amenorrhea, hirsutism, and infertility. Women with PCOS also have insulin resistance and are at high risk for developing impaired glucose tolerance and diabetes mellitus. Weight loss usually normalizes SHBG and estradiol levels for individuals with simple obesity, but weight loss may not restore fertility to patients with severe PCOS.
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