Immunoregulatory Effects

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Cromolyn and nedocromil have a wide spectrum of activity that includes: inhibition of mediator release from mast cells, eosinophils, and neutrophils; protection against allergen-induced and exercise-induced bronchospasm; and prevention of the early- and late-phase asthmatic response (3).

Sheard and Blair were the first to report that CS prevented the antigen-induced release of histamine and SRS-A (leukotrienes) from passively sensitized human lung (33). More recently, pretreatment of rat peritoneal mast cells with DSCG prior to anti-DNP exposure resulted in significant inhibition of histamine release in a dose-dependent manner (34) (Fig. 5).

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Coping with Asthma

Coping with Asthma

If you suffer with asthma, you will no doubt be familiar with the uncomfortable sensations as your bronchial tubes begin to narrow and your muscles around them start to tighten. A sticky mucus known as phlegm begins to produce and increase within your bronchial tubes and you begin to wheeze, cough and struggle to breathe.

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