Immunoregulatory Effects

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Cromolyn and nedocromil have a wide spectrum of activity that includes: inhibition of mediator release from mast cells, eosinophils, and neutrophils; protection against allergen-induced and exercise-induced bronchospasm; and prevention of the early- and late-phase asthmatic response (3).

Sheard and Blair were the first to report that CS prevented the antigen-induced release of histamine and SRS-A (leukotrienes) from passively sensitized human lung (33). More recently, pretreatment of rat peritoneal mast cells with DSCG prior to anti-DNP exposure resulted in significant inhibition of histamine release in a dose-dependent manner (34) (Fig. 5).

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