Cromone Mechanism of Action

Phramacology Astma

The exact mechanism of action of cromolyn and nedocromil has not been determined. Multiple mechanisms involving ion channel blockade, blockade of signaling of heat shock protein or G-protein, or even blockade of capsaicin receptor have been identified. However, the final common mechanism appears to be an inhibition of mast cell activation. Studies have reported that the phosphorylation of a 78-kDa-molecular-weight protein prevents mediator release in mast cells (17). More specifically in rat...