Vitamin E

♦ Vitamin E is an antioxidant.

♦ Observational studies suggested that vitamin E may have a neuroprotective effect on decreasing the risk of Parkinson's disease.

♦ Zhang et al. (2002) evaluated the incidence of PD in two large cohorts of men and women who completed detailed and validated semiquantitative food frequency questionnaires. A total of 371 incident PD cases were ascertained in the Nurses' Health Study, which comprised 76,890 women who were followed for 14 years, and the Health Professionals Follow-Up Study, which comprised 47,331 men who were followed for 12 years. They found that neither intake of total vitamins E or C nor use of vitamin E or vitamin C supplements or multivitamins was significantly associated with decreased risk of PD. The risk of PD, however, was significantly reduced among men and women with high intake of dietary vitamin E from foods only.

The DATATOP study (1993) found that vitamin E in doses of 2,000 IU did not delay the need for levodopa treatment in patients with early PD. A meta-analysis by Miller et al (2005) of 19 clinical trials found that high-dosage vitamin E supplementation (400 IU/day for at least 1 year) may increase all-cause mortality. Benefits or risks of lower-dosage supplementation were unclear.

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