Coenzyme Q10

♦ CoQ10 is an antioxidant and a component of the energy-producing electron transport chain of mitochondria.

♦ It is currently being investigated as a neuro-protective agent.

♦ A double-blind, placebo-controlled pilot study in PD found that high doses of CoQ10

(1200 mg/day) were associated with a reduced rate of deterioration in motor function from baseline over 16 months. This result should be considered preliminary and further studies will be required.

♦ A futility study, sponsored by the NIH, is currently under way. Researchers are investigating doses of CoQ10 as high as 2400 mg/day.

♦ Tested formulations have usually included vitamin E (as did the placebo).

♦ Use of CoQ10 is usually not covered by insurance and high doses are relatively expensive.

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