Tauopathies Including Progressive Supranuclear Palsy and Other Tau Related Disorders

Super Memory Formula

Chinese Treatments for Memory Loss

Get Instant Access

The low molecular weight microtubule-associated protein tau has been implicated in a number of neurodegenerative diseases, including Alzheimer's disease, PSP, Pick's disease, frontotemporal dementia with parkinsonism (FTDP), and amyotrophic lateral sclerosis/parkinsonism-dementia complex (ALS/PDC) of Guam. Together these neurodegenerative diseases are referred to as tauopathies since they share common neuropathological features, including abnormal hyper-phosphorylation and filamentous accumulation of aggregated tau proteins (224). Reports have implicated either alternative RNA splicing (generating different isoforms) or missense mutations as mechanisms underlying many of the tauopathies. Therefore, transgenic mice have been generated that over-express specific splice variants or missense mutation of tau (225). One such transgenic line has been developed to over-express the shortest human tau isoform (226). These mice showed progressive motor weakness, intraneuronal and intra-axonal inclusions (detectable by one-month postnatal), and reduced axonal transport. Fibrillary tau inclusions developed in the neocortical neurons after 18 months of age implicating age-specific processes in the pathogenesis of fibrous tau inclusions. An interesting tau transgenic has been developed in D. melanogaster where expression of a tau missense mutation showed no evidence of large filamentous aggregates (neurofibrillary tangles). However, aged flies showed evidence of vacuolization and degeneration of cortical neurons (227). These observations suggest that tau-mediated neurodegeneration is age-dependent and may take place independent of protein aggregation.

Was this article helpful?

0 0
All About Alzheimers

All About Alzheimers

The comprehensive new ebook All About Alzheimers puts everything into perspective. Youll gain insight and awareness into the disease. Learn how to maintain the patients emotional health. Discover tactics you can use to deal with constant life changes. Find out how counselors can help, and when they should intervene. Learn safety precautions that can protect you, your family and your loved one. All About Alzheimers will truly empower you.

Get My Free Ebook


Post a comment