Anticholinergics have relatively few clinical uses in PD other than the treatment of tremor in young-onset patients. Anticholinergics can be used in younger patients with PD-associated dystonia unresponsive to or intolerant of dopaminergic medications. Secondary anticholinergic effects may occasionally be helpful for sialorrhea or increased urinary frequency. Appropriate caution remains in judging risks of side effects versus benefits in anticholinergic use, particularly in patients who may be more susceptible to either the central or peripheral anticholinergic effects.
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