Neuropsychological Aspects Of Parkinsonplus Syndromes And Essential Tremor

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"Parkinson-plus syndromes" traditionally include PSP, MSA, and corticobasal degeneration (CBD). Although sparse, preliminary neuropsychological studies indicate that the cognitive impairment profiles likely differ across the parkinson-plus syndromes (172). A summary of key differences is presented in Table 4.

TABLE 4 Comparison of Neurobehavioral Features of Parkinson's Disease with Dementia, Lewy Body Dementia, Corticobasal Degeneration, Progressive Supranuclear Palsy, and Multiple System Atrophy

PDD

LBD

CBD

PSP

MSA

Attention

-

--

-

-

--

Executive (e.g., problem-solving,

conceptualization, planning,

flexibility)

--

--

-

--

0/-

Language

Letter fluency

--

--

-

-/--

-

Category fluency

--

--

-

-

-

Visual confrontation naming

0/-

-/--

0/-

0

0

Memory for new information

Recall

--

-/--

0/-

0/-

0/-

Recognition

0/-

-

0

0

0

Memory for old information

-

?

?

0

0

Praxis

0/-

0/-

--

0/-

0

Alien-hand sign

0

0

-/--

0

0

Visuoperceptual/constructional

functions

-

--

-

-

-

Depression

--

--

-

0/-

0/-

Apathy

-

-

-

--

--

Fluctuating cognition

0/-

--

0

0

0

Abbreviations: 0, impairment absent; -, mild to moderate impairment; --, moderate to severe impairment;?, questionable; PDD, Parkinson's disease with dementia; LBD, Lewy body dementia; CBD, corticobasal degeneration; PSP, progressive supranuclear palsy; MSA, multiple system atrophy.

Abbreviations: 0, impairment absent; -, mild to moderate impairment; --, moderate to severe impairment;?, questionable; PDD, Parkinson's disease with dementia; LBD, Lewy body dementia; CBD, corticobasal degeneration; PSP, progressive supranuclear palsy; MSA, multiple system atrophy.

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