The Parkinson's-Reversing Breakthrough

What is Parkinsons Disease

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Anxiety and depression have become recognized as common nonmotor, psychiatric comorbidities in idiopathic Parkinson's disease (PD), which contribute to additional disability such as significant impairments of cognitive, functional, motor, and social performance. This leads to reductions in quality of life and increased caregiver distress (1-8). Preliminary data suggest that depression may be an independent predictor of mortality in patients with PD (9). However, these affective disorders are under-recognized and under-treated in patients with PD due to symptom overlap with motor and cognitive features of PD (10-12).

In the presence of other comorbid psychiatric conditions (e.g., anxiety), depressive symptoms, quality of life, and functional domains are further worsened. Specifically, the presence of anxiety with depression has been found to increase the severity of depressive symptoms and to delay the response to psychotropic treatment (13). Therefore, effective detection and treatment of anxiety and depression are important aspects of PD management. This chapter will discuss the epidemiology, possible mechanisms, recognition, and management of these affective disorders in idiopathic PD.

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