Duodenal infusions of levodopa have been used in a small number of PD subjects for years. One group reported 28 advanced PD patients with on/off fluctuations who received a median of 1050 mg/day of Duodopa (levodopa gel; Solvay, NeoPharma) for a median of 44 months (range 2-83 months). They reported significant benefits of Duodopa that were maintained for up to 7 years (2). A recent report demonstrated improved quality of life and amelioration of fluctuations in six advanced PD patients using Duodopa, with a mean infusion rate of 88 mg/hr starting at 8 am and ending at 11 pm (3). Large, multicenter studies are planned.
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