O

Obesity, as risk factor for ovarian cancer, 7 OCCR (ovarian cancer cluster region), of BRCA2, 36, 37f Occult malignancy, 57-58 Omental caking, imaging of, 75f, 76 Oophorectomy for advanced-stage epithelial cancer, 113-117, 114f,

115f, 116f bilateral prophylactic for BRCA mutations, 42 in general population, 56-57 for hereditary nonpolyposis colorectal cancer, 46 in high-risk population, 57-60, 61t procedure for, 58, 58f-59f and risk reduction, 132-133, 132f vs. screening, 102, 104, 104b for borderline tumor, 197 for germ cell tumors, 135, 136t for granulosa cell tumors, 202 Oral contraceptives, and risk reduction, 4, 51, 53 in general population, 53-54, 55t for women with increased risk, 55-56, 56t

0V-10 trial, 157

Ovarian cancer cluster region (OCCR), of BRCA2, 36, 37f Ovarian carcinogenesis model clinical and pathologic observations supporting dualistic, 18 molecular evidence supporting, 22-27, 23f in borderline tumors, 26, 26t in clear cell carcinoma, 19t, 20, 27 in endometrioid carcinoma, 19t, 20, 27 in malignant Brenner (transitional) tumor, 19t, 20 in malignant mixed mesodermal tumor

(carcinosarcoma), 19t in mucinous carcinoma, 19t, 20, 26-27 in serous carcinoma, 22-26

allelic imbalance and chromosomal instability as, 25-26

apolipoprotein E overexpression as, 25 BRAF and KRAS mutations as, 21, 22-23, 22t, 23f HLA-G overexpression as, 22t, 25 p53 mutation as, 22t, 23f, 24, 24f proliferation (ki-67) index as, 22t in undifferentiated carcinoma, 19t proposal for, 18-21 type I tumors in, 20, 20f clinicopathologic features of, 22t molecular features of, 22t precursors and molecular genetic alterations of, 19t type II tumors in, 20-21, 20f clinicopathologic features of, 22t gross appearance of, 21f microscopic appearance of, 21f molecular features of, 22t precursors and molecular genetic alterations of, 19t Ovulation, as risk factor for ovarian cancer, 3-4, 52 OVX1 (Lewis X mucin determinant), for screening, 95

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment