Molecular Alterations in Other Nonserous Types of Ovarian Carcinomas

The stepwise progression of borderline tumors (atypical proliferative tumor and noninvasive MPSC) to the low-grade serous carcinoma (invasive MPSC) closely approximates the adenoma-carcinoma sequence in colorectal carcinoma. This tumor progression model is also applicable to other type I carcinomas, specifically mucinous and endometrioid carcinoma. Accordingly, these mucinous and endome-trioid borderline tumors have been thought to represent an intermediate stage in the stepwise progression to mucinous and endometrioid carcinoma, respectively (Table 2-5).

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